Electrocardiographic effects of hawthorn (Crataegus oxyacantha) in healthy volunteers: A randomized controlled trial.

Autor: Trexler SE; Department of Pharmacy Practice, University of Connecticut School of Pharmacy, Storrs, CT, USA., Nguyen E; Department of Pharmacy, Hartford Hospital, Hartford, CT, USA., Gromek SM; Division of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA., Balunas MJ; Division of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA., Baker WL; Department of Pharmacy Practice, University of Connecticut School of Pharmacy, Storrs, CT, USA.
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2018 Aug; Vol. 32 (8), pp. 1642-1646. Date of Electronic Publication: 2018 Apr 19.
DOI: 10.1002/ptr.6094
Abstrakt: The objective of this study was to evaluate the electrocardiographic effects of hawthorn in healthy adult volunteers. It was double-blind cross-over trial randomized 20 healthy adult volunteers to receive either a single oral 160-mg dose of hawthorn or matching placebo. Triplicate 12-lead electrocardiograms were taken before treatment and at 1-, 2-, 4-, and 6-hr post-dose. Following at least a 7-day washout period, participants were crossed over to the opposing treatment arm and had the measurements repeated. The primary endpoint was the change in corrected (Fridericia) QT intervals (QT c I) at 4 and 6 hr. Maximum post-dose QT c I and changes in PR and QRS intervals were measured. No significant differences in 4- or 6-hr QT c I were seen between hawthorn and placebo. Maximum post-dose QT c I in the hawthorn and placebo groups were similar (346 ± 35 vs 346 ± 40 ms; p = .979). No significant adverse events were seen. In conclusion, a single dose of oral hawthorn had no effect on electrocardiographic parameters in healthy volunteers.
(Copyright © 2018 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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