Scintillation Yield Estimates of Colloidal Cerium-Doped LaF 3 Nanoparticles and Potential for "Deep PDT".

Autor: Kudinov KA; a   Department of Chemistry., Cooper DR; c   Medical Physics Unit, Faculty of Medicine, McGill University, Montreal, Canada., Ha JK; b   Department of Radiation Oncology, Keck Medical School, University of Southern California, Los Angeles, California., Hill CK; b   Department of Radiation Oncology, Keck Medical School, University of Southern California, Los Angeles, California., Nadeau JL; d   Graduate Aerospace Laboratories, Division of Engineering and Applied Sciences, California Institute of Technology, Pasadena, California., Seuntjens JP; c   Medical Physics Unit, Faculty of Medicine, McGill University, Montreal, Canada., Bradforth SE; a   Department of Chemistry.
Jazyk: angličtina
Zdroj: Radiation research [Radiat Res] 2018 Jul; Vol. 190 (1), pp. 28-36. Date of Electronic Publication: 2018 Apr 19.
DOI: 10.1667/RR14944.1
Abstrakt: A hybrid of radiotherapy and photodynamic therapy (PDT) has been proposed in previously reported studies. This approach utilizes scintillating nanoparticles to transfer energy to attached photosensitizers, thus generating singlet oxygen for local killing of malignant cells. Its effectiveness strongly depends upon the scintillation yield of the nanoparticles. Using a liquid scintillator as a reference standard, we estimated the scintillation yield of Ce 0.1 La 0.9 F 3 /LaF 3 core/shell nanoparticles at 28.9 mg/ml in water to be 350 photons/MeV under orthovoltage X-ray irradiation. The subsequent singlet oxygen production for a 60 Gy cumulative dose to cells was estimated to be four orders of magnitude lower than the "Niedre killing dose," used as a target value for effective cell killing. Without significant improvements in the radioluminescence properties of the nanoparticles, this approach to "deep PDT" is likely to be ineffective. Additional considerations and alternatives to singlet oxygen are discussed.
Databáze: MEDLINE
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