Subclinical cardiovascular disease parameters after one year in new users of depot medroxyprogesterone acetate compared to copper-IUD.

Autor: Cursino K; a Department of Obstetrics and Gynecology, Family Planning Clinic , University of Campinas Medical School , Campinas , Brazil., de Lima GA; a Department of Obstetrics and Gynecology, Family Planning Clinic , University of Campinas Medical School , Campinas , Brazil., de Nazaré Silva Dos Santos P; a Department of Obstetrics and Gynecology, Family Planning Clinic , University of Campinas Medical School , Campinas , Brazil., Pavin EJ; b Department of Clinical Medicine , University of Campinas Medical School , Campinas , Brazil., Bahamondes L; a Department of Obstetrics and Gynecology, Family Planning Clinic , University of Campinas Medical School , Campinas , Brazil., Fernandes A; a Department of Obstetrics and Gynecology, Family Planning Clinic , University of Campinas Medical School , Campinas , Brazil.
Jazyk: angličtina
Zdroj: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception [Eur J Contracept Reprod Health Care] 2018 Jun; Vol. 23 (3), pp. 201-206. Date of Electronic Publication: 2018 Apr 19.
DOI: 10.1080/13625187.2018.1455087
Abstrakt: Purpose: To evaluate markers of cardiovascular disease in women with normal insulin sensitivity who had recently initiated use of depot medroxyprogesterone acetate (DMPA) as a contraceptive.
Materials and Methods: A prospective, non-randomised, comparative study. Data of 30 women of 18-40 years of age, with normal hyperinsulinaemic-euglycaemic clamp at baseline and body mass index (BMI) < 30, who opted to use DMPA or a copper intrauterine device (IUD) as a contraceptive, were analysed. Serum samples were collected for evaluation of the lipid and hepatic profile, C-reactive protein, TNF-α, interleukin-6, leptin/adiponectin ratio and free fatty acids; body composition was evaluated using DXA, blood pressure and carotid intima-media thickness were measured. Evaluations were performed at baseline and 12 months later. The groups were compared using repeated measures analysis of variance (ANOVA). Significance level was 5%.
Results: The mean age of the women in the DMPA and IUD group was 28.7 ± 6.5 and 28.3 ± 5.8 years, respectively; the BMI was 23.0 ± 3.4 and 24.3 ± 2.7 kg/m 2 , respectively, in the same groups. At 12 months, triglyceride levels were higher in the DMPA group compared to the IUD group and there was an increase in apolipoprotein B-100 in relation to baseline in DMPA group; there were no other difference between the groups.
Conclusions: No clinical cardiovascular effect was found but deterioration in CV markers was observed in the first year of use of DMPA.
Databáze: MEDLINE
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