Caloric restriction delays yeast chronological aging by remodeling carbohydrate and lipid metabolism, altering peroxisomal and mitochondrial functionalities, and postponing the onsets of apoptotic and liponecrotic modes of regulated cell death.

Autor:	Arlia-Ciommo A; Department of Biology, Concordia University, Montreal, Quebec, Canada., Leonov A; Department of Biology, Concordia University, Montreal, Quebec, Canada., Beach A; Department of Biology, Concordia University, Montreal, Quebec, Canada., Richard VR; Department of Biology, Concordia University, Montreal, Quebec, Canada., Bourque SD; Department of Biology, Concordia University, Montreal, Quebec, Canada., Burstein MT; Department of Biology, Concordia University, Montreal, Quebec, Canada., Kyryakov P; Department of Biology, Concordia University, Montreal, Quebec, Canada., Gomez-Perez A; Department of Biology, Concordia University, Montreal, Quebec, Canada., Koupaki O; Department of Biology, Concordia University, Montreal, Quebec, Canada., Feldman R; Department of Biology, Concordia University, Montreal, Quebec, Canada., Titorenko VI; Department of Biology, Concordia University, Montreal, Quebec, Canada.
Jazyk:	angličtina
Zdroj:	Oncotarget [Oncotarget] 2018 Mar 05; Vol. 9 (22), pp. 16163-16184. Date of Electronic Publication: 2018 Mar 05 (Print Publication: 2018).
DOI:	10.18632/oncotarget.24604
Abstrakt:	A dietary regimen of caloric restriction delays aging in evolutionarily distant eukaryotes, including the budding yeast Saccharomyces cerevisiae . Here, we assessed how caloric restriction influences morphological, biochemical and cell biological properties of chronologically aging yeast advancing through different stages of the aging process. Our findings revealed that this low-calorie diet slows yeast chronological aging by mechanisms that coordinate the spatiotemporal dynamics of various cellular processes before entry into a non-proliferative state and after such entry. Caloric restriction causes a stepwise establishment of an aging-delaying cellular pattern by tuning a network that assimilates the following: 1) pathways of carbohydrate and lipid metabolism; 2) communications between the endoplasmic reticulum, lipid droplets, peroxisomes, mitochondria and the cytosol; and 3) a balance between the processes of mitochondrial fusion and fission. Through different phases of the aging process, the caloric restriction-dependent remodeling of this intricate network 1) postpones the age-related onsets of apoptotic and liponecrotic modes of regulated cell death; and 2) actively increases the chance of cell survival by supporting the maintenance of cellular proteostasis. Because caloric restriction decreases the risk of cell death and actively increases the chance of cell survival throughout chronological lifespan, this dietary intervention extends longevity of chronologically aging yeast. Competing Interests: CONFLICTS OF INTEREST The authors declare no conflicts of interest.
Databáze:	MEDLINE
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