17-hydroxiprogesterone values in healthy preterm infants.

Autor: Mendoza-Rojas VC; Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia., Díaz-Martínez LA; Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia., Mantilla-Mora G; Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia., Contreras-García GA; Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia., Mora-Bautista VM; Programa de Especialización en Pediatría, Departamento de Pediatría, Escuela de Medicina; Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia., Martínez-Paredes JF; Programa de Medicina, Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia., Calderón-Rojas AL; Programa de Medicina, Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia., Gómez-Tarazona CA; Programa de Medicina, Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia., Pinzón-Mantilla K; Programa de Microbiología y Bioanálisis, Escuela de Microbiología, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia.
Jazyk: angličtina
Zdroj: Colombia medica (Cali, Colombia) [Colomb Med (Cali)] 2017 Dec 30; Vol. 48 (4), pp. 161-166. Date of Electronic Publication: 2017 Dec 30.
DOI: 10.25100/cm.v43i4.2983
Abstrakt: Introduction: In preterm newborn, problems with the interpretation of 17-OHP may occur.
Objective: Evaluate 17-OHP values in healthy preterm newborns until they reach the corrected gestational age.
Methods: Longitudinal study of 36 preterm infants with 17-OHP evaluation using ELISA from heel blood from 3 to 5 days and thereafter every 2 weeks until the corrected gestational age. Values adjusting multiple variables such as gestational age, birth weight and sex, among others were compared. The results were analyzed against 82 healthy full-term infants.
Results: In the first week of life, early term infants born within less than 34 months of gestational age show 17-OHP values that are much higher than the full term neonates. After a week, the values decrease and stabilize, but are still higher than those of full term neonates and remain so even at the corrected gestational age. (average difference of 63.0%, CI 95%: 11.8%-115.5%). 33.6% (41 samples) of a total of 122 samples taken from preterm infants were higher than 30 ng/mL.
Conclusions: 17-OHP values in early term infants are higher than those in full term neonates and can be related to postnatal adaptive processes. It is suggested that a second screening at the 37th week of corrected age be performed.
Databáze: MEDLINE
Externí odkaz: