Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures.

Autor: McCafferty C; Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK. mccaffertycp@cardiff.ac.uk.; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA. mccaffertycp@cardiff.ac.uk., David F; Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK.; Team Waking, Lyon Neuroscience Research Center, CRNL, INSERM U1028, CNRS UMR5292, University of Lyon 1, Lyon, France., Venzi M; Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK., Lőrincz ML; Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary., Delicata F; Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK.; Department of Physiology and Biochemistry, University of Malta, Msida, Malta., Atherton Z; Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK., Recchia G; Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK., Orban G; Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK.; Department of Physiology and Biochemistry, University of Malta, Msida, Malta., Lambert RC; Sorbonne Université, CNRS, Inserm, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), Paris, France., Di Giovanni G; Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK.; Department of Physiology and Biochemistry, University of Malta, Msida, Malta., Leresche N; Sorbonne Université, CNRS, Inserm, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), Paris, France., Crunelli V; Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK. crunelli@cardiff.ac.uk.; Department of Physiology and Biochemistry, University of Malta, Msida, Malta. crunelli@cardiff.ac.uk.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2018 May; Vol. 21 (5), pp. 744-756. Date of Electronic Publication: 2018 Apr 16.
DOI: 10.1038/s41593-018-0130-4
Abstrakt: Behaviorally and pathologically relevant cortico-thalamo-cortical oscillations are driven by diverse interacting cell-intrinsic and synaptic processes. However, the mechanism that gives rise to the paroxysmal oscillations of absence seizures (ASs) remains unknown. Here we report that, during ASs in behaving animals, cortico-thalamic excitation drives thalamic firing by preferentially eliciting tonic rather than T-type Ca 2+ channel (T-channel)-dependent burst firing in thalamocortical (TC) neurons and by temporally framing thalamic output via feedforward reticular thalamic (NRT)-to-TC neuron inhibition. In TC neurons, overall ictal firing was markedly reduced and bursts rarely occurred. Moreover, blockade of T-channels in cortical and NRT neurons suppressed ASs, but such blockade in TC neurons had no effect on seizures or on ictal thalamic output synchrony. These results demonstrate ictal bidirectional cortico-thalamic communications and provide the first mechanistic understanding of cortico-thalamo-cortical network firing dynamics during ASs in behaving animals.
Databáze: MEDLINE
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