Serotonergic gene polymorphisms (5-HTTLPR, 5HTR1A, 5HTR2A), and population differences in aggression: traditional (Hadza and Datoga) and industrial (Russians) populations compared.

Autor: Butovskaya ML; Department of Cross-Cultural Psychology and Human Ethology, Institute of Ethnology and Anthropology, Russian Academy of Sciences, Leninsky Ave. 32a, Moscow, Russia, 119334. marina.butovskaya@gmail.com.; Faculty of History, Lomonosov Moscow State University, Lomonosovsky Ave. 27-4, Moscow, Russia, 119192. marina.butovskaya@gmail.com.; Russian State University for the Humanities, Miusskaya Sq. 6, GSP-3, Moscow, Russia, 125993. marina.butovskaya@gmail.com., Butovskaya PR; Group for Population Immunogenetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina St. 3, Moscow, Russia, 119333., Vasilyev VA; Department of Genome Organization, Institute of Gene Biology, Russian Academy of Sciences, Vavilova St. 34/5, Moscow, Russia, 119334., Sukhodolskaya JM; Department of Genome Organization, Institute of Gene Biology, Russian Academy of Sciences, Vavilova St. 34/5, Moscow, Russia, 119334., Fekhredtinova DI; Department of Genome Organization, Institute of Gene Biology, Russian Academy of Sciences, Vavilova St. 34/5, Moscow, Russia, 119334., Karelin DV; Faculty of Biology, Lomonosov Moscow State University, Leninskie Gory 1-12, Moscow, Russia, 119991., Fedenok JN; Department of Cross-Cultural Psychology and Human Ethology, Institute of Ethnology and Anthropology, Russian Academy of Sciences, Leninsky Ave. 32a, Moscow, Russia, 119334., Mabulla AZP; Department of Archaeology and Heritage, University of Dar es Salaam, P.O. Box 35091, Dar es Salaam, Tanzania., Ryskov AP; Department of Genome Organization, Institute of Gene Biology, Russian Academy of Sciences, Vavilova St. 34/5, Moscow, Russia, 119334., Lazebny OE; Department of Evolutionary and Developmental Genetics, Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Vavilova St. 26, Moscow, Russia, 119334.
Jazyk: angličtina
Zdroj: Journal of physiological anthropology [J Physiol Anthropol] 2018 Apr 16; Vol. 37 (1), pp. 10. Date of Electronic Publication: 2018 Apr 16.
DOI: 10.1186/s40101-018-0171-0
Abstrakt: Background: Current knowledge on genetic basis of aggressive behavior is still contradictory. This may be due to the fact that the majority of studies targeting associations between candidate genes and aggression are conducted on industrial societies and mainly dealing with various types of psychopathology and disorders. Because of that, our study was carried on healthy adult individuals of both sex (n = 853).
Methods: Three populations were examined: two traditional (Hadza and Datoga) and one industrial (Russians), and the association of aggression with the following polymorphisms 5-HTTLPR, rs6295 (5HTR1A gene), and rs6311 (5HTR2A gene) were tested. Aggression was measured as total self-ratings on Buss-Perry Aggression Questionnaire.
Results: Distributions of allelic frequencies of 5-HTTLPR and 5HTR1A polymorphisms were significantly different among the three populations. Consequently, the association analyses for these two candidate genes were carried out separately for each population, while for the 5HTR2A polymorphism, it was conducted on the pooled data that made possible to introduce ethnic factor in the ANOVA model. The traditional biometrical approach revealed no sex differences in total aggression in all three samples. The three-way ANOVA (μ + 5-HTTLPR + 5HTR1A + 5HTR2A +ε) with measures of self-reported total aggression as dependent variable revealed significant effect of the second serotonin receptor gene polymorphism for the Hadza sample. For the Datoga, the interaction effect between 5-HTTLPR and 5HTR1A was significant. No significant effects of the used polymorphisms were obtained for Russians. The results of two-way ANOVA with ethnicity and the 5HTR2A polymorphism as main effects and their interactions revealed the highly significant effect of ethnicity, 5HTR2A polymorphism, and their interaction on total aggression.
Conclusions: Our data provided obvious confirmation for the necessity to consider the population origin, as well as cultural background of tested individuals, while searching for associations between genes and behavior, and demonstrated the role of cultural attitudes towards the use of in-group aggression. Our data partly explained the reasons for disagreement in results of different teams, searching for candidate-gene associations with behavior without considerations of culturally desirable norms. Previous studies suggested that the 5HTR2A gene polymorphism associates with aggression and criminality. Our data extended these findings, demonstrating the role of rs6311 (5HTR2A gene) in aggression in adult healthy men and women from our samples. We found that G-allele carriers were rated higher on total aggression.
Databáze: MEDLINE
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