Pathogenetic Role of Endothelial Dysfunction in Idiopathic Vestibulopathy.

Autor: Udut EV; National Research Tomsk State University, Tomsk, Russia. evu8@mail.ru.; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. evu8@mail.ru., Shchetinin PP; National Research Tomsk State University, Tomsk, Russia., Rudenko TV; National Research Tomsk State University, Tomsk, Russia., Lucieer F; Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and Neuroscience, Maastricht, the Netherlands., Kingma H; National Research Tomsk State University, Tomsk, Russia.; Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and Neuroscience, Maastricht, the Netherlands., Shchetinina AP; National Research Tomsk State University, Tomsk, Russia., Pleshkov MO; National Research Tomsk State University, Tomsk, Russia., Demkin VP; National Research Tomsk State University, Tomsk, Russia., Udut VV; National Research Tomsk State University, Tomsk, Russia.; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2018 Apr; Vol. 164 (6), pp. 726-729. Date of Electronic Publication: 2018 Apr 16.
DOI: 10.1007/s10517-018-4067-0
Abstrakt: Comparative analysis of the groups of patients with idiopathic bilateral vestibular hypofunction and a group of vestibulopathy patients with vertebrobasilar insufficiency demonstrated identity of the basic and additional diagnostic parameters in these syndromes as well as similarity in clinical diagnostic and anamnesis data. In all cases, functional assessment of endothelium-dependent vasodilation and selected biochemical marker sICAM-1 revealed endothelial dysfunction. Drug correction of endothelial dysfunction positively affected the manifestations of major and minor features of the syndrome, which confirmed the contribution of endothelial functional disturbances to the pathogenesis of bilateral vestibular hypofunction.
Databáze: MEDLINE
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