The Educated Guess: Determining Drug Doses in Exotic Animals Using Evidence-Based Medicine.
| Autor: | Visser M; Department of Anatomy, Physiology and Pharmacology, Auburn University, 1010 Wire Road, Auburn, AL 36849, USA. Electronic address: visserm0512@gmail.com., Oster SC; Department of Clinical Science, Auburn University, 1500 Wire Road, Auburn, AL 36849, USA. |
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| Jazyk: | angličtina |
| Zdroj: | The veterinary clinics of North America. Exotic animal practice [Vet Clin North Am Exot Anim Pract] 2018 May; Vol. 21 (2), pp. 183-194. |
| DOI: | 10.1016/j.cvex.2018.01.002 |
| Abstrakt: | Lack of species-specific pharmacokinetic and pharmacodynamic data is a challenge for pharmaceutical and dose selection. If available, dose extrapolation can be accomplished via basic equations. If unavailable, several methods have been described. Linear scaling uses an established milligrams per kilograms dose based on weight. This does not allow for differences in species drug metabolism, sometimes resulting in toxicity. Allometric scaling correlates body weight and metabolic rate but fails for drugs with significant hepatic metabolism and cannot be extrapolated to avians or reptiles. Evidence-based veterinary medicine for dose design based on species similarity is discussed, considering physiologic differences between classes. (Copyright © 2018 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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