Fluorine-18-fluorodeoxyglucose PET/CT in hematopoietic stem cell transplant patients with fusariosis: initial findings of a case series review.

Autor:	Schirmer MR; Nacional Cancer Institute José Alencar Gomes da Silva (INCA), Bone Marrow Transplant Center (CEMO), Rio de Janeiro, RJ, Brazil., Carneiro MP; Nacional Cancer Institute José Alencar Gomes da Silva (INCA), Nuclear Medicine Service, Rio de Janeiro, RJ, Brazil.; Rio de Janeiro State University (UERJ), University Hospital Pedro Ernesto, Nuclear Medicine Service, Rio de Janeiro, RJ, Brazil.; D’Or Institute for Reseach and Teaching (IDOR), Rio de Janeiro, RJ, Brazil., Machado LS; Nacional Cancer Institute José Alencar Gomes da Silva (INCA), Nuclear Medicine Service, Rio de Janeiro, RJ, Brazil., Chaves ALDS; Nacional Cancer Institute José Alencar Gomes da Silva (INCA), Clinical Pathology Division, Rio de Janeiro, RJ, Brazil., Lopes FPPL; Federal University of Rio de Janeiro (UFRJ), Faculty of Medicine, Radiology Department, Rio de Janeiro, RJ, Brazil.; DASA Clinic for Image Diagnostics (CDPI), Rio de Janeiro, RJ, Brazil.; Villela Pedras Nuclear Medicine Clinic, Rio de Janeiro, RJ, Brazil.
Jazyk:	angličtina
Zdroj:	Nuclear medicine communications [Nucl Med Commun] 2018 Jun; Vol. 39 (6), pp. 545-552.
DOI:	10.1097/MNM.0000000000000834
Abstrakt:	Background: Fusariosis is an opportunistic fungal infection that affects mostly leukemic and hematopoietic stem cell transplant patients. Locally invasive and disseminated infection may occur. Treatment is challenging, and besides evaluation of immune status, one also needs to take into account organ involvement to predict the duration and prognosis. Objective: The aim of this study was to present the findings and clinical follow-up from a series of cases of Fusarium spp. infections in patients subjected to hematopoietic stem cell transplant evaluated with one or more fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT scans, according to the source of clinical culture sample (blood or wound secretion). Results: Ten patients were included. In this series, 18F-FDG PET/CT was able to detect osteomyelitis in three patients. Conclusion: Although having a small number of patients and lack of standard approach, 18F-FDG PET/CT seemed useful to discriminate uncomplicated cases of primary bloodstream infections and detect occult foci of metastatic infection in patients with positive cutaneous lesions cultures.
Databáze:	MEDLINE
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