Small de novo CNVs as biomarkers of parental exposure to low doses of ionizing radiation of caesium-137.

Autor:	Costa EOA; Pontifical Catholic University of Goiás, Department of Agricultural and Biological Sciences, Genetics Master's Program, Replicon Research Group, Rua 235, n. 40, Bloco L, Área IV - S. Universitário, CEP 74605-050, Goiânia-GO, Brazil.; Catholic University of Brasilia, Genomic Sciences and Biotechnology Graduate Program, Brasilia-DF, Brazil., Pinto IP; Pontifical Catholic University of Goiás, Department of Agricultural and Biological Sciences, Genetics Master's Program, Replicon Research Group, Rua 235, n. 40, Bloco L, Área IV - S. Universitário, CEP 74605-050, Goiânia-GO, Brazil.; University of Brasília, Biotechnology and Biodiversity PhD Program, Brasilia-DF, Brazil., Gonçalves MW; Pontifical Catholic University of Goiás, Department of Agricultural and Biological Sciences, Genetics Master's Program, Replicon Research Group, Rua 235, n. 40, Bloco L, Área IV - S. Universitário, CEP 74605-050, Goiânia-GO, Brazil.; Federal University of Goiás, Graduate Program in Genetics and Molecular Biology, Institute of Biological Sciences, Goiânia-GO, Brazil., da Silva JF; Pontifical Catholic University of Goiás, Department of Agricultural and Biological Sciences, Genetics Master's Program, Replicon Research Group, Rua 235, n. 40, Bloco L, Área IV - S. Universitário, CEP 74605-050, Goiânia-GO, Brazil., Oliveira LG; Pontifical Catholic University of Goiás, Department of Agricultural and Biological Sciences, Genetics Master's Program, Replicon Research Group, Rua 235, n. 40, Bloco L, Área IV - S. Universitário, CEP 74605-050, Goiânia-GO, Brazil., da Cruz AS; Pontifical Catholic University of Goiás, Department of Agricultural and Biological Sciences, Genetics Master's Program, Replicon Research Group, Rua 235, n. 40, Bloco L, Área IV - S. Universitário, CEP 74605-050, Goiânia-GO, Brazil., Silva DME; Federal University of Goiás, Graduate Program in Genetics and Molecular Biology, Institute of Biological Sciences, Goiânia-GO, Brazil., da Silva CC; Pontifical Catholic University of Goiás, Department of Agricultural and Biological Sciences, Genetics Master's Program, Replicon Research Group, Rua 235, n. 40, Bloco L, Área IV - S. Universitário, CEP 74605-050, Goiânia-GO, Brazil.; Human Cytogenetics and Molecular Genetics Laboratory, Health Secretary of Goiás State, Goiânia-GO, Brazil.; University of Brasília, Biotechnology and Biodiversity PhD Program, Brasilia-DF, Brazil.; State University of Goiás, UnU Goiania, Goiânia-GO, Brazil., Pereira RW; Catholic University of Brasilia, Genomic Sciences and Biotechnology Graduate Program, Brasilia-DF, Brazil., da Cruz AD; Pontifical Catholic University of Goiás, Department of Agricultural and Biological Sciences, Genetics Master's Program, Replicon Research Group, Rua 235, n. 40, Bloco L, Área IV - S. Universitário, CEP 74605-050, Goiânia-GO, Brazil. acruz@pucgoias.edu.br.; Human Cytogenetics and Molecular Genetics Laboratory, Health Secretary of Goiás State, Goiânia-GO, Brazil. acruz@pucgoias.edu.br.; University of Brasília, Biotechnology and Biodiversity PhD Program, Brasilia-DF, Brazil. acruz@pucgoias.edu.br.; Federal University of Goiás, Graduate Program in Genetics and Molecular Biology, Institute of Biological Sciences, Goiânia-GO, Brazil. acruz@pucgoias.edu.br.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2018 Apr 12; Vol. 8 (1), pp. 5914. Date of Electronic Publication: 2018 Apr 12.
DOI:	10.1038/s41598-018-23813-5
Abstrakt:	The radiological accident in Goiania in 1987 caused a trail of human contamination, animal, plant and environmental by a radionuclide. Exposure to ionizing radiation results in different types of DNA lesions. The mutagenic effects of ionizing radiation on the germline are special concern because they can endures for several generations, leading to an increase in the rate of mutations in children of irradiated parents. Thus, to evaluate the biological mechanisms of ionizing radiation in somatic and germline cells, with consequent determination of the rate mutations, is extremely important for the estimation of genetic risks. Recently it was established that Chromosomal Microarray Analysis is an important tool for detecting wide spectra of gains or losses in the human genome. Here we present the results of the effect of accidental exposure to low doses of ionizing radiation on the formation of CNVs in the progeny of a human population accidentally exposed to Caesium-137 during the radiological accident in Goiânia, Brazil.
Databáze:	MEDLINE
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