Insulin-like growth factor-I (IGF-I) and IGF-I receptor in human testis: an immunohistochemical study.

Autor: Vannelli BG; Department of Human Anatomy, University of Florence, Italy., Barni T, Orlando C, Natali A, Serio M, Balboni GC
Jazyk: angličtina
Zdroj: Fertility and sterility [Fertil Steril] 1988 Apr; Vol. 49 (4), pp. 666-9.
DOI: 10.1016/s0015-0282(16)59837-9
Abstrakt: Using specific monoclonal antibodies, the authors studied the distribution of insulin growth factor-I (IGF-I) and its receptor in normal human testis by immunostaining techniques. IGF-I was preferentially localized in Sertoli cells. Less evident positivity was found in primary spermatocytes. In the interstitium some Leydig cells were positive for IGF-I. The major positivity for the IGF-I receptor was found in secondary spermatocytes and early spermatids, whereas Sertoli cells were less positive. An intense positivity was found in some Leydig cells.
Databáze: MEDLINE