Perinuclear antineutrophil cytoplasmic antibody-positive vasculitis, oligoarthritis, tendinitis, and myositis associated with isotretinoin in a 15-year-old boy: Case report and review of literature.

Autor: Mangodt TC; Department of Pediatrics, Queen Paola Children's Hospital, Antwerp, Belgium.; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium., Joos R; Department of Pediatrics, Queen Paola Children's Hospital, Antwerp, Belgium.; Department of Pediatric Rheumatology, University Hospital of Ghent, Ghent, Belgium., Siozopoulou V; Department of Pathology, University Hospital of Antwerp, Antwerp, Belgium., Cortoos PJ; Pharmacy, University Hospital of Brussels, Brussels, Belgium., Baeten H; Department of Pediatrics, Queen Paola Children's Hospital, Antwerp, Belgium.; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium., Docx M; Department of Pediatrics, Queen Paola Children's Hospital, Antwerp, Belgium.; Department of Chronic Pediatric Diseases and Nephrology, Queen Paola Children's Hospital, Antwerp, Belgium., van den Akker M; Department of Pediatrics, Queen Paola Children's Hospital, Antwerp, Belgium.; Department of Pediatric Hematology and Oncology, University Hospital of Brussels, Brussels, Belgium.
Jazyk: angličtina
Zdroj: Pediatric dermatology [Pediatr Dermatol] 2018 May; Vol. 35 (3), pp. e173-e177. Date of Electronic Publication: 2018 Apr 11.
DOI: 10.1111/pde.13445
Abstrakt: We present a patient in whom a combination of perinuclear antineutrophil cytoplasmic antibody-positive vasculitis, oligoarthritis, tendinitis, and myositis was considered to be associated with isotretinoin use. Discontinuation of the drug resulted in complete clinical and biochemical remission (normalization of perinuclear antineutrophil cytoplasmic antibody titer). Although we were unable to prove causality, no other underlying cause for the patient's course was found. We report this occurrence to bring it to the attention of physicians prescribing isotretinoin.
(© 2018 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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