The Association between TGF-β1 G915C (Arg25Pro) Polymorphism and the Development of Primary Open Angle Glaucoma: A Case-Control Study.

Autor:	Karmiris E; Department of Ophthalmology, University of Athens, Athens, Greece.; Department of Ophthalmology, Hellenic Air Force General Hospital, Athens, Greece., Kourtis N; Department of Ophthalmology, University of Athens, Athens, Greece.; Department of Ophthalmology, 424 Hellenic Army Hospital, Athens, Greece., P Pantou M; Molecular Immunopathology and Histocompatibility Laboratory, Onassis Cardiac Surgery Center, Athens, Greece., Degiannis D; Molecular Immunopathology and Histocompatibility Laboratory, Onassis Cardiac Surgery Center, Athens, Greece., Georgalas I; Department of Ophthalmology, University of Athens, Athens, Greece., Papaconstantinou D; Department of Ophthalmology, University of Athens, Athens, Greece.
Jazyk:	angličtina
Zdroj:	Medical hypothesis, discovery & innovation ophthalmology journal [Med Hypothesis Discov Innov Ophthalmol] 2018 Spring; Vol. 7 (1), pp. 25-31.
Abstrakt:	The purpose of the current study was to identify the potential association between Single Nucleotide Polymorphism (SNP) TGFβ1 +915 (C or G) in codon 25 and Primary Open Angle Glaucoma (POAG). Overall, 88 cases with POAG and a control group of 52 healthy individuals were recruited from the First Ophthalmology Department of Athens University. DNA was isolated from whole blood samples and genotype frequencies for the polymorphism rs1800471 (G915C, Arg25Pro) of the TGF-β1 gene were assessed. Genotype distribution frequencies for the polymorphism rs1800471 (G915C, Arg25Pro) of the TGF-β1 gene were not statistically different between patients with POAG and control subjects. The present study failed to determine any significant genotypic association with POAG, despite the fact that the presence of the C allele was scarcely increased in the POAG when compared with the control group. Competing Interests: No funding or sponsorship was received for this study. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship, take responsibility for the integrity of the work as a whole, and have given final approval for the version to be published.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu