Mismatch in Brain Perfusion and Metabolism Detected with 99m Tc-Hexamethyl Propylene Amine Oxime Single Photon Emission Computed Tomography and 18 F-Fluorodeoxyglucose Positron Emission Tomography in Moyamoya Disease.
| Autor: | Vicente JS; Department of Nuclear Medicine, Infanta Cristina Hospital, Badajoz, Spain., Prudencio LF; Department of Nuclear Medicine, Infanta Cristina Hospital, Badajoz, Spain., Torre JRI; Department of Nuclear Medicine, Infanta Cristina Hospital, Badajoz, Spain., Madrid JIR; Department of Nuclear Medicine, Infanta Cristina Hospital, Badajoz, Spain. |
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| Jazyk: | angličtina |
| Zdroj: | Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India [Indian J Nucl Med] 2018 Apr-Jun; Vol. 33 (2), pp. 154-157. |
| DOI: | 10.4103/ijnm.IJNM_2_18 |
| Abstrakt: | We report a 47-year-old woman who developed an ischemic stroke with diplopia and dysarthria. Emergency computed tomography (CT) showed no pathological findings, and magnetic resonance (MR) showed mild ischemic-degenerative lesions. MR angiography and angiogram showed severe stenosis of both internal carotid and main intracranial arteries with plenty collateral vessels with "puff of smoke" suggesting a moyamoya disease (MMD). Brain perfusion single-photon emission CT showed global diminished perfusion in the brain lobes and a marked relative hyperperfusion in the cerebellum. However, brain 18 F-fluorodeoxyglucose-positron emission tomography showed physiological metabolism in the brain cortex with only slightly relative cerebellar hypermetabolism. MMD is a well-known arterial pathology that frequently develops with only mild symptoms until the middle age. Functional neuroimaging findings indicate a mismatch between brain glucose metabolism and brain perfusion, probably due to neuronal subclinical chronic ischemia in the brain cortex with preserved viability of neurons. Competing Interests: There are no conflicts of interest. |
| Databáze: | MEDLINE |
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