| Autor: |
Sakaine G; Latvian Institute of Organic Synthesis , Aizkraukles 21 , Riga LV-1006 , Latvia., Smits G; Latvian Institute of Organic Synthesis , Aizkraukles 21 , Riga LV-1006 , Latvia. |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of organic chemistry [J Org Chem] 2018 May 04; Vol. 83 (9), pp. 5323-5330. Date of Electronic Publication: 2018 Apr 18. |
| DOI: |
10.1021/acs.joc.8b00643 |
| Abstrakt: |
A formal total synthesis of pyrrolo[1,4]benzodiazepine anticancer antibiotic family member limazepine E is described. The synthesis features a stereoselective introduction of a trisubstituted double bond using novel sterically demanding Julia-Kocienski reagents, allowing the number of linear steps to be significantly reduced. The potential of the newly developed reagents has also been demonstrated by the formal total synthesis of barmumycin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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