| Autor: |
Lefevre T; MIVEGEC, IRD, CNRS University of Montpellier Montpellier France.; Institut de Recherche en Sciences de la Santé (IRSS) Bobo Dioulasso Burkina Faso.; Laboratoire Mixte International sur les Vecteurs (LAMIVECT) Bobo Dioulasso Burkina Faso., Ohm J; Department of Entomology and Center for Infectious Disease Dynamics Penn State University University Park PA USA., Dabiré KR; Institut de Recherche en Sciences de la Santé (IRSS) Bobo Dioulasso Burkina Faso.; Laboratoire Mixte International sur les Vecteurs (LAMIVECT) Bobo Dioulasso Burkina Faso., Cohuet A; MIVEGEC, IRD, CNRS University of Montpellier Montpellier France., Choisy M; MIVEGEC, IRD, CNRS University of Montpellier Montpellier France.; Oxford University Clinical Research Unit Hanoi Vietnam., Thomas MB; Department of Entomology and Center for Infectious Disease Dynamics Penn State University University Park PA USA., Cator L; Grand Challenges in Ecosystems and Environment Imperial College London Ascot UK. |
| Jazyk: |
angličtina |
| Zdroj: |
Evolutionary applications [Evol Appl] 2017 Dec 16; Vol. 11 (4), pp. 456-469. Date of Electronic Publication: 2017 Dec 16 (Print Publication: 2018). |
| DOI: |
10.1111/eva.12571 |
| Abstrakt: |
Evaluating the risk of emergence and transmission of vector-borne diseases requires knowledge of the genetic and environmental contributions to pathogen transmission traits. Compared to the significant effort devoted to understanding the biology of malaria transmission from vertebrate hosts to mosquito vectors, the strategies that malaria parasites have evolved to maximize transmission from vectors to vertebrate hosts have been largely overlooked. While determinants of infection success within the mosquito host have recently received attention, the causes of variability for other key transmission traits of malaria, namely the duration of parasite development and its virulence within the vector, as well as its ability to alter mosquito behavior, remain largely unknown. This important gap in our knowledge needs to be bridged in order to obtain an integrative view of the ecology and evolution of malaria transmission strategies. Associations between transmission traits also need to be characterized, as they trade-offs and constraints could have important implications for understanding the evolution of parasite transmission. Finally, theoretical studies are required to evaluate how genetic and environmental influences on parasite transmission traits can shape malaria dynamics and evolution in response to disease control. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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