Sex Differences in the Relationship Between Left Ventricular Diastolic Dysfunction and Coronary Artery Disease: From the Korean Women's Chest Pain Registry.

Autor:	Cho DH; 1 Department of Cardiology, Korea University Anam Hospital, Korea University Cardiovascular Center , Seoul, Korea., Kim MA; 2 Department of Cardiology, Seoul National University Boramae Hospital , Seoul, Korea., Choi J; 3 Department of Cardiology, Department of Biostatistics, College of Medicine, Korea University , Seoul, Korea., Kim MN; 1 Department of Cardiology, Korea University Anam Hospital, Korea University Cardiovascular Center , Seoul, Korea., Park SM; 1 Department of Cardiology, Korea University Anam Hospital, Korea University Cardiovascular Center , Seoul, Korea., Kim HL; 2 Department of Cardiology, Seoul National University Boramae Hospital , Seoul, Korea., Yoon HJ; 4 Department of Cardiology, Chonnam National University Hospital , Gwangju, Korea., Shin MS; 5 Department of Cardiology, Gachon Medical School Gil Medical Center , Incheon, Korea., Hong KS; 6 Department of Cardiology, Hallym University Chuncheon Sacred Heart Hospital , Chuncheon, Korea., Shim WJ; 1 Department of Cardiology, Korea University Anam Hospital, Korea University Cardiovascular Center , Seoul, Korea.
Jazyk:	angličtina
Zdroj:	Journal of women's health (2002) [J Womens Health (Larchmt)] 2018 Jul; Vol. 27 (7), pp. 912-919. Date of Electronic Publication: 2018 Mar 20.
DOI:	10.1089/jwh.2017.6610
Abstrakt:	Background: Although coronary artery disease (CAD) is an important comorbidity, the influence of CAD on left ventricular diastolic dysfunction (LVDD) is not clear. This study aims to assess differences in the relationship between CAD and LVDD according to sex and comorbidities. Materials and Methods: A total of 1109 consecutive patients who visited an outpatient clinic with chest pain were included. The outcomes in 295 men and 295 women were compared after propensity score 1:1 matching. The evaluation of LVDD was based on guidelines recommended by the American Society of Echocardiography. The presence and severity of obstructive CAD was assessed by coronary angiography. Results: After propensity score matching, both men and women were well balanced, with no significant differences of baseline covariates. Differences in diastolic functional parameters according to CAD severity were observed only in women (three parameters of LVDD except e' velocity, p < 0.05). Multiple logistic regression for matched pair data demonstrated that CAD severity was associated with the presence of LVDD only in women (odds ratio 1.919, 95% confidence interval 1.343-2.741, p < 0.001). Interaction between sex and severity of CAD was significant (p = 0.025). Conclusions: The association of LVDD and CAD severity was observed only in women. Myocardial ischemia may be a potential pathophysiology for higher prevalence of LVDD and heart failure with preserved ejection fraction in women.
Databáze:	MEDLINE
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