Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients.

Autor: Matser YAH; VU University Medical Center, Amsterdam, The Netherlands., Terpstra ML; Department of Nephrology, Academic Medical Centre, Amsterdam, The Netherlands., Nadalin S; Department of General, Visceral and Transplantation Surgery, University of Tübingen, Tübingen, Germany., Nossent GD; Department of Lung Transplantation, University Medical Center Groningen, Groningen, The Netherlands., de Boer J; Eurotransplant, International Foundation, Leiden, The Netherlands., van Bemmel BC; Department of Pathology, Martini Hospital, Groningen, The Netherlands., van Eeden S; Department of Pathology, Academic Medical Centre, Amsterdam, The Netherlands., Budde K; Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany., Brakemeier S; Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany., Bemelman FJ; Department of Nephrology, Academic Medical Centre, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2018 Jul; Vol. 18 (7), pp. 1810-1814. Date of Electronic Publication: 2018 Apr 27.
DOI: 10.1111/ajt.14766
Abstrakt: We report 4 cases of breast cancer transmission to transplant recipients from a single organ donor that occurred years after donation. The diagnosis of breast cancer was occult at the time of donation. All of the recipients developed a histologically similar type of breast cancer within 16 months to 6 years after transplantation. Three out of 4 recipients died as a result of widely metastasized disease. One of the recipients survived after transplant nephrectomy followed by cessation of immunosuppression and chemotherapy. This extraordinary case points out the often fatal consequences of donor-derived breast cancer and suggests that removal of the donor organ and restoration of immunity can induce complete remission.
(© 2018 The American Society of Transplantation and the American Society of Transplant Surgeons.)
Databáze: MEDLINE
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