Positive Surgical Margins in the 10 Most Common Solid Cancers.

Autor:	Orosco RK; Division of Otolaryngology, Head and Neck Surgery, University of California, San Diego, CA, USA., Tapia VJ; Division of Otolaryngology, Head and Neck Surgery, University of California, San Diego, CA, USA., Califano JA; Division of Otolaryngology, Head and Neck Surgery, University of California, San Diego, CA, USA.; Department of Surgery, University of California, San Diego, CA, USA.; Moores Cancer Center, University of California, San Diego, CA, USA., Clary B; Department of Surgery, University of California, San Diego, CA, USA., Cohen EEW; Moores Cancer Center, University of California, San Diego, CA, USA.; Department of Medicine, Division of Hematology-Oncology, University of California, San Diego, CA, USA., Kane C; Moores Cancer Center, University of California, San Diego, CA, USA.; Department of Urology, University of California, San Diego, CA, USA., Lippman SM; Moores Cancer Center, University of California, San Diego, CA, USA.; Department of Medicine, Division of Hematology-Oncology, University of California, San Diego, CA, USA., Messer K; Moores Cancer Center, University of California, San Diego, CA, USA., Molinolo A; Moores Cancer Center, University of California, San Diego, CA, USA., Murphy JD; Department of Radiation Medicine and Applied Sciences, San Diego, CA, USA., Pang J; Division of Otolaryngology, Head and Neck Surgery, University of California, San Diego, CA, USA., Sacco A; Moores Cancer Center, University of California, San Diego, CA, USA.; Department of Medicine, Division of Hematology-Oncology, University of California, San Diego, CA, USA., Tringale KR; Division of Otolaryngology, Head and Neck Surgery, University of California, San Diego, CA, USA., Wallace A; Department of Surgery, University of California, San Diego, CA, USA.; Moores Cancer Center, University of California, San Diego, CA, USA., Nguyen QT; Division of Otolaryngology, Head and Neck Surgery, University of California, San Diego, CA, USA. q1nguyen@ucsd.edu.; Department of Surgery, University of California, San Diego, CA, USA. q1nguyen@ucsd.edu.; Department of Pharmacology, University of California, San Diego, CA, USA. q1nguyen@ucsd.edu.; Moores Cancer Center, University of California, San Diego, CA, USA. q1nguyen@ucsd.edu.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2018 Apr 09; Vol. 8 (1), pp. 5686. Date of Electronic Publication: 2018 Apr 09.
DOI:	10.1038/s41598-018-23403-5
Abstrakt:	A positive surgical margin (PSM) following cancer resection oftentimes necessitates adjuvant treatments and carries significant financial and prognostic implications. We sought to compare PSM rates for the ten most common solid cancers in the United States, and to assess trends over time. Over 10 million patients were identified in the National Cancer Data Base from 1998-2012, and 6.5 million had surgical margin data. PSM rates were compared between two time periods, 1998-2002 and 2008-2012. PSM was positively correlated with tumor category and grade. Ovarian and prostate cancers had the highest PSM prevalence in women and men, respectively. The highest PSM rates for cancers affecting both genders were seen for oral cavity tumors. PSM rates for breast cancer and lung and bronchus cancer in both men and women declined over the study period. PSM increases were seen for bladder, colon and rectum, and kidney and renal pelvis cancers. This large-scale analysis appraises the magnitude of PSM in the United States in order to focus future efforts on improving oncologic surgical care with the goal of optimizing value and improving patient outcomes.
Databáze:	MEDLINE
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