Effect of IFN-λ2 on combined allergic rhinitis with nasal polyps.

Autor: Wang YT; Department of Otolaryngology, Jining First People's Hospital of Shandong Province, Jining, Shandong Province, China. liu_chunxiu1@163.com., Wang H, Wang FL, Qian XM, Zhuang SF, Yang MX, Liu CX
Jazyk: angličtina
Zdroj: European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2018 Mar; Vol. 22 (6), pp. 1588-1594.
DOI: 10.26355/eurrev_201803_14563
Abstrakt: Objective: This study sought to investigate the expression of interferon-λ2 (IFN-λ2) in patients with combined allergic rhinitis and nasal polyps (AR+NP), analyze the correlation between IFN-λ2 and tryptase, interleukin 10 (IL-10), and interleukin 12 (IL-12), and identify its peripheral blood cell origins.
Patients and Methods: ELISA kits were used to investigate plasma levels of IFN-λ2, tryptase, IL-10, and IL-12 in AR+NP patients and healthy controls (HC). Flow cytometry analysis was carried out to detect IFN-λ2 expression in peripheral blood leukocytes. Immunocytochemical staining was performed to detect nasal polyp IFN-λ2 expression in AR+NP patients.
Results: Elevated plasma IFN-λ2 levels and positive correlations between plasma IFN-λ2 and tryptase levels in AR+NP patients indicated that IFN-λ2 likely contributes to AR+NP pathogenesis. IFN-λ2 expression was upregulated in cytotoxic T cells and eosinophils in AR+NP patients. Nasal polyp mast cells and macrophages in AR+NP patients expressed IFN-λ2.
Conclusions: The close correlation between IFN-λ2 expression and AR+NP may provide experimental evidence for a possible effect of IFN-λ2 against the allergic inflammatory reaction. Therefore, IFN-λ2 actions may have a potential utility for the treatment and prevention of AR+AP.
Databáze: MEDLINE