| Autor: |
Frensemeier LM; Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstr. 28/30, 48149 Münster, Germany. christian.kowol@univie.ac.at uk@uni-muenster.de., Mayr J, Koellensperger G, Keppler BK, Kowol CR, Karst U |
| Jazyk: |
angličtina |
| Zdroj: |
The Analyst [Analyst] 2018 Apr 30; Vol. 143 (9), pp. 1997-2001. |
| DOI: |
10.1039/c8an00258d |
| Abstrakt: |
Pt(iv) prodrugs are a class of promising anticancer agents, which are activated by reduction to the active Pt(ii) species. Consequently, the reduction process is a crucial parameter. Herein, a new approach using electrochemistry (EC) coupled to liquid chromatography (LC) and electrospray ionization-mass spectrometry (ESI-MS) or inductively coupled plasma (ICP)-MS was applied. This enabled getting insights into the differences in the reduction and ligand release of platinum(iv) complexes with varying equatorial core structures. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
