| Autor: |
Trannoy E; Laboratoire d'Immunodifférenciation, Institut Jacques Monod, Centre National de la Recherche Scientifique, Université Paris, France., Regnier D, Morisset J, Seman M |
| Jazyk: |
angličtina |
| Zdroj: |
Immunology letters [Immunol Lett] 1987 Nov; Vol. 16 (2), pp. 163-7. |
| DOI: |
10.1016/0165-2478(87)90125-8 |
| Abstrakt: |
Immunization of mice with the p-azobenzenearsonate-L-tyrosine conjugate (ABA-Tyr) leads to the activation of ABA-specific T helper cells capable of proliferating in vitro in the presence of the corresponding antigen. This response is under a dual genetic regulation by H-2 and non-H-2 linked genes, and H-2d mice are high-responder. We demonstrate here, using strains congenic to BALB/c for chromosomes (Chr.) 6 or 12 that this T cell response is also influenced by kappa and IgH linked genes. Double congenic mice indicate that Chr.6 and Chr.12 genes have a complementary effect on the response which cannot be predicted solely by the alleles expressed on either of the two chromosomes. In addition, responses in Bailey's inbred recombinant mice allow a possible mapping of the Chr.12 gene at the 5' end of the IgH complex and of the VH-dextran gene family. The mechanisms which may account for the influence of immunoglobulin gene products on the ABA-specific T cell repertoire are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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