Evaluation of the intracellular activity of drugs against Mycobacterium abscessus using a THP-1 macrophage model.

Autor: Molina-Torres CA; Servicio de Dermatología, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, N.L., Mexico. Electronic address: carmelia7@hotmail.com., Tamez-Peña L; Servicio de Dermatología, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, N.L., Mexico., Castro-Garza J; Centro de Investigación Biomédica del Noreste, IMSS, Monterrey, N.L., Mexico., Ocampo-Candiani J; Servicio de Dermatología, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, N.L., Mexico., Vera-Cabrera L; Servicio de Dermatología, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, N.L., Mexico.
Jazyk: angličtina
Zdroj: Journal of microbiological methods [J Microbiol Methods] 2018 May; Vol. 148, pp. 29-32. Date of Electronic Publication: 2018 Apr 04.
DOI: 10.1016/j.mimet.2018.03.020
Abstrakt: We evaluated the antimicrobial effectiveness against M. abscessus in a THP-1 cell line model. No intracellular activity was observed when using amikacin or imipenem. A bacteriostatic effect was observed for cefoxitin, clarithromycin and azithromycin. Tigecycline showed the best antibacterial effect by decreasing the intracellular growth up to bactericidal level.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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