Homocysteine is the confounding factor of metabolic syndrome-confirmed by siMS score.

Autor:	Srećković B; Clinical Center Bežanijska Kosa, 11000 Belgrade, Serbia., Soldatovic I; Institute for Medical Statistics and Informatics, Belgrade, Serbia., Colak E; Institute of Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia., Mrdovic I; Clinic for Cardiovascular Diseases, Emergency Center, Belgrade, Serbia., Sumarac-Dumanovic M; Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia and Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Janeski H; University Children's Hospital, Belgrade, Serbia., Janeski N; Clinical Center Zemun, Belgrade, Serbia., Gacic J; Clinical Center Bežanijska Kosa, Belgrade, Serbia., Dimitrijevic-Sreckovic V; Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia and Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Jazyk:	angličtina
Zdroj:	Drug metabolism and personalized therapy [Drug Metab Pers Ther] 2018 Jun 27; Vol. 33 (2), pp. 99-103.
DOI:	10.1515/dmpt-2017-0013
Abstrakt:	Background: Abdominal adiposity has a central role in developing insulin resistance (IR) by releasing pro-inflammatory cytokines. Patients with metabolic syndrome (MS) have higher values of homocysteine. Hyperhomocysteinemia correlates with IR, increasing the oxidative stress. Oxidative stress causes endothelial dysfunction, hypertension and atherosclerosis. The objective of the study was to examine the correlation of homocysteine with siMS score and siMS risk score and with other MS co-founding factors. Methods: The study included 69 obese individuals (age over 30, body mass index [BMI] >25 kg/m2), classified into two groups: I-with MS (33 patients); II-without MS (36 patients). Measurements included: anthropometric parameters, lipids, glucose regulation parameters and inflammation parameters. IR was determined by homeostatic model assessment for insulin resistance (HOMA-IR). ATP III classification was applied for diagnosing MS. SiMS score was used as continuous measure of metabolic syndrome. Results: A significant difference between groups was found for C-reactive protein (CRP) (p<0.01) apolipoprotein (Apo) B, HOMA-IR and acidum uricum (p<0.05). siMS risk score showed a positive correlation with homocysteine (p=0.023), while siMS score correlated positively with fibrinogen (p=0.013), CRP and acidum uricum (p=0.000) and homocysteine (p=0.08). Homocysteine correlated positively with ApoB (p=0.036), HbA1c (p=0.047), HOMA-IR (p=0.008) and negatively with ApoE (p=0.042). Conclusions: Correlation of siMS score with homocysteine, fibrinogen, CRP and acidum uricum indicates that they are co-founding factors of MS. siMS risk score correlation with homocysteine indicates that hyperhomocysteinemia increases with age. Hyperhomocysteinemia is linked with genetic factors and family nutritional scheme, increasing the risk for atherosclerosis.
Databáze:	MEDLINE
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