Neisseria meningitidis disease-associated clones in Amazonas State, Brazil.

Autor: Silva LA; a Laboratory of Microbial Diversity of Importance to Health and Laboratory of Communicable Disease Ecology , Leônidas & Maria Deane Institute, FIOCRUZ , Manaus , Brazil., Coronato B; b Laboratory of Epidemiology and Molecular Systematics , Oswaldo Cruz Institute, FIOCRUZ , Rio de Janeiro , Brazil., Schlackman J; c Infectious Diseases Epidemiology Research Unit , University of Pittsburgh School of Medicine and Graduate School of Public Health , Pittsburgh , PA , USA., Marsh JW; c Infectious Diseases Epidemiology Research Unit , University of Pittsburgh School of Medicine and Graduate School of Public Health , Pittsburgh , PA , USA., Ezeonwuka C; c Infectious Diseases Epidemiology Research Unit , University of Pittsburgh School of Medicine and Graduate School of Public Health , Pittsburgh , PA , USA., Fernandes ACL; b Laboratory of Epidemiology and Molecular Systematics , Oswaldo Cruz Institute, FIOCRUZ , Rio de Janeiro , Brazil., Souza VC; a Laboratory of Microbial Diversity of Importance to Health and Laboratory of Communicable Disease Ecology , Leônidas & Maria Deane Institute, FIOCRUZ , Manaus , Brazil., da Silva LS; a Laboratory of Microbial Diversity of Importance to Health and Laboratory of Communicable Disease Ecology , Leônidas & Maria Deane Institute, FIOCRUZ , Manaus , Brazil., de Amorim EFQ; a Laboratory of Microbial Diversity of Importance to Health and Laboratory of Communicable Disease Ecology , Leônidas & Maria Deane Institute, FIOCRUZ , Manaus , Brazil., Naveca FG; a Laboratory of Microbial Diversity of Importance to Health and Laboratory of Communicable Disease Ecology , Leônidas & Maria Deane Institute, FIOCRUZ , Manaus , Brazil., de Albuquerque BC; d Department of Epidemiological Surveillance and Central Laboratory , Foundation of Health Surveillance of Amazonas , Manaus , AM , Brazil., Amaral A; d Department of Epidemiological Surveillance and Central Laboratory , Foundation of Health Surveillance of Amazonas , Manaus , AM , Brazil., Souza ALS; d Department of Epidemiological Surveillance and Central Laboratory , Foundation of Health Surveillance of Amazonas , Manaus , AM , Brazil., Carvalho-Costa FA; b Laboratory of Epidemiology and Molecular Systematics , Oswaldo Cruz Institute, FIOCRUZ , Rio de Janeiro , Brazil.; e Regional Technical Office, FIOCRUZ , Teresina , Brazil., Mustapha MM; c Infectious Diseases Epidemiology Research Unit , University of Pittsburgh School of Medicine and Graduate School of Public Health , Pittsburgh , PA , USA., Harrison LH; c Infectious Diseases Epidemiology Research Unit , University of Pittsburgh School of Medicine and Graduate School of Public Health , Pittsburgh , PA , USA., Barroso DE; b Laboratory of Epidemiology and Molecular Systematics , Oswaldo Cruz Institute, FIOCRUZ , Rio de Janeiro , Brazil.
Jazyk: angličtina
Zdroj: Infectious diseases (London, England) [Infect Dis (Lond)] 2018 Sep; Vol. 50 (9), pp. 697-704. Date of Electronic Publication: 2018 Apr 06.
DOI: 10.1080/23744235.2018.1459829
Abstrakt: Background: The aim of this study is to describe the molecular epidemiology of Neisseria meningitidis invasive disease before the introduction of serogroup C conjugate vaccine in Amazonas State in 2010.
Methods: Meningococcal disease reported cases were investigated in Amazonas State during the period 2000-2010. N. meningitidis isolates (n = 196) recovered from patients were genotyped by multilocus sequence typing (MLST) and sequencing of porB, porA, fetA, fHbp and penA. Antimicrobial susceptibility was determined using E-test.
Results: In the study period, 948 cases were reported; the incidence was 2.8 for the entire state and 4.8 per 100,000 in the capital of Manaus. Most meningococcal disease was caused by N. meningitidis belonging to ST-32 (72%; 141/196) or ST-103 (21%; 41/196) clonal complexes. Capsular switching (B→C) was suggested within clonal complex (cc) 32. There were 6 (3%; 6/196) strains with intermediate susceptibility to penicillin and a single strain was resistant to rifampicin. Since 2007, serogroup C strains belonging to the cc103 have predominated and case-fatality has increased.
Conclusion: We demonstrate a high rate of meningococcal disease in Amazonas State, where, like other parts of Brazil, serogroup C replaced serogroup B during 2000s. These data serve as a baseline to measure impact of serogroup C conjugate vaccine introduction in 2010. This study emphasizes the need for enhanced surveillance to monitor changes in meningococcal disease trends following the introduction of meningococcal vaccines.
Databáze: MEDLINE
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