| Autor: |
Badial RM; Department of Biology, São Paulo State University - UNESP, São José do Rio Preto/SP Department of Obstetrics and Gynecology, Hospital of Ribeirão Preto School of Medicine - HC-FMRP Department of Gynecology and Obstetrics, Medical School of Ribeirão Preto, University of São Paulo - USP Department of Epidemiology and Public Health, Faculty of Medicine of São José do Rio Preto - FAMERP, São José do Rio Preto/SP, Brazil Institute of Pharmacology, University of Bern, Bern, Switzerland., Dias MC, Stuqui B, Melli PPDS, Quintana SM, Bonfim CMD, Cordeiro JA, Rabachini T, Calmon MF, Provazzi PJS, Rahal P |
| Jazyk: |
angličtina |
| Zdroj: |
Medicine [Medicine (Baltimore)] 2018 Apr; Vol. 97 (14), pp. e9545. |
| DOI: |
10.1097/MD.0000000000009545 |
| Abstrakt: |
HPV have been identified as high-risk and low-risk, depending on their association with the development of cancer. HPV infections can be facilitated by co-infection with HIV. Here, we investigated HPV prevalence and genotypes and the risk factors affecting HPV/HIV co-infection. Forty HIV-positive patients had 80 cervical swab samples collected in 2 consecutive years. Polymerase chain reaction and DNA direct sequencing were used to perform HPV genotyping. Statistical analyses were performed regarding risk factors for HPV/HIV co-infection and the occurrence of cervical lesions. HPV DNA was detected in 59 samples (73.75%), and high-risk HPVs were predominant (59.3%). The most prevalent type was HPV56 (17%), followed by HPV16 (15.3%). Patient age did not affect the risk of cervical cancer (P = .84) or HPV prevalence in different years (P = .25/P = .63). CD4 count also did not affect the risk for cervical lesions in the tested samples (P = .15/P = .28). Although the HIV viral load was not correlated with an increase in cervical lesion detection in the first group of analyzed samples (P = .12), it did affect cervical cancer risk in the group of samples analyzed in the following year (P = .045). HIV-infected patients presented a high prevalence of HPV co-infection, and HPV16 and HPV56 were the most prevalent genotypes. Considering this, it is possible that immunodeficiency can contribute to increased susceptibility to HPV56 infection in HIV-infected patients. The association between HIV viral load and the lesions also confirmed the importance of monitoring HIV/HPV co-infected patients with high HIV viral loads. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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