A NEW COPPER (II)-IMIDAZOLE DERIVATIVE EFFECTIVELY INHIBITS REPLICATION OF DENV-2 IN VERO CELL.

Autor: Sucipto TH; Dengue Study Group, Institute of Tropical Disease, Airlangga University, Kampus C Jl. Mulyorejo, Surabaya, East Java, Indonesia, 60115., Churrotin S; Dengue Study Group, Institute of Tropical Disease, Airlangga University, Kampus C Jl. Mulyorejo, Surabaya, East Java, Indonesia, 60115., Setyawati H; Department of Chemistry, Faculty of Science and Technology, Airlangga University, Kampus C Jl. Mulyorejo, Surabaya, East Java, Indonesia, 60115., Martak F; Department of Chemistry, Faculty of Mathematic and Natural Science, Sepuluh Nopember Institute of Technology, Kampus Sukolilo Jl. Raya ITS, Surabaya, East Java, Indonesia, 60111., Mulyatno KC; Dengue Study Group, Institute of Tropical Disease, Airlangga University, Kampus C Jl. Mulyorejo, Surabaya, East Java, Indonesia, 60115., Amarullah IH; Dengue Study Group, Institute of Tropical Disease, Airlangga University, Kampus C Jl. Mulyorejo, Surabaya, East Java, Indonesia, 60115., Kotaki T; Department of International Health, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe, Hyogo 654-0142, Japan., Kameoka M; Department of International Health, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe, Hyogo 654-0142, Japan., Yotopranoto S; Dengue Study Group, Institute of Tropical Disease, Airlangga University, Kampus C Jl. Mulyorejo, Surabaya, East Java, Indonesia, 60115., Soegijanto AS; Dengue Study Group, Institute of Tropical Disease, Airlangga University, Kampus C Jl. Mulyorejo, Surabaya, East Java, Indonesia, 60115.
Jazyk: angličtina
Zdroj: African journal of infectious diseases [Afr J Infect Dis] 2018 Mar 07; Vol. 12 (1 Suppl), pp. 116-119. Date of Electronic Publication: 2018 Mar 07 (Print Publication: 2018).
DOI: 10.2101/Ajid.12v1S.17
Abstrakt: Background: Dengue is a kind of infectious disease that was distributed in the tropical and sub-tropical areas. To date, there is no clinically approved dengue vaccine or antiviral for humans, even though there have been great efforts towards this end. Therefore, finding the effective compound against dengue virus (DENV) replication is very important. Among the complex compounds, copper(II)-imidazole derivatives are of interest because of their biological and medicinal benefits.
Materials and Methods: In the present study, antiviral activity of [Cu(2,4,5-triphenylimidazole) 2 ] n , was evaluated against different stages of dengue virus type 2 (DENV-2) replication in Vero cell using focus forming unit reduction assay and quantitative ELISA.
Results: [Cu(2,4,5-triphenylimidazole) 2 ] n inhibited DENV-2 replication in Vero cells with IC 50 = 2.3 μg/ml and SI= 19.42 when cells were treated 2 days after virus infection, whereas its CC 50 for cytotoxicity to Vero cells was 44.174 μg/ml.
Conclusion: The compound has high anti-DENV2 activity, less toxicity, and a high possibility to be considered a drug candidate.
Competing Interests: Conflict of Interest: Authors declare that they have no competing interest.
Databáze: MEDLINE
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