Multiple drug resistance and biocide resistance in Escherichia coli environmental isolates from hospital and household settings.

Autor: Ghanem B; Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, The University of Jordan, Amman, 11942 Jordan., Haddadin RN; Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, The University of Jordan, Amman, 11942 Jordan.
Jazyk: angličtina
Zdroj: Antimicrobial resistance and infection control [Antimicrob Resist Infect Control] 2018 Apr 02; Vol. 7, pp. 47. Date of Electronic Publication: 2018 Apr 02 (Print Publication: 2018).
DOI: 10.1186/s13756-018-0339-8
Abstrakt: Background: Antibiotic resistance of environmental Escherichia coli in hospitals could be increased due to extensive use of biocides resulting in serious infections. In this study, the prevalence of antibiotic resistance of environmental isolates of E. coli from hospitals and household settings were evaluated and compared. In addition, the association between biocide minimum inhibitory concentration (MIC) and multiple drug resistance (MDR) was investigated.
Methods: Environmental samples were collected from different homes and hospitals in Amman, Jordan. The isolates were identified phenotypically and by PCR. Antibiotic susceptibility tests and MIC of selected biocides were performed on the isolates. Screening for bla CTX-M group 1 was also performed.
Results: Of 21 E. coli strains isolated, 47.6% were MDR and 67.9% were phenotypically identified as extended spectrum beta-lactamase (ESBL) producers. The occurrence of these ESBL isolates was comparable between household and hospital settings ( P  > 0.05). The MIC values of the biocides tested against all isolates were well below the in-use concentration of biocides. Moreover, the MICs of biocides were comparable between isolates from households and those from hospitals ( P  > 0.05). No association was found between MDR and biocide MIC (P > 0.05). Most of ESBL isolates harboured bla CTX-M 1.
Conclusions: The extensive use of biocides in hospitals is not associated with MDR nor does it affect the MIC of biocides against E.coli .
Competing Interests: Not applicableNot applicableThe authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Databáze: MEDLINE
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