Topical heat shock protein 70 prevents imiquimod-induced psoriasis-like inflammation in mice.

Autor: Seifarth FG; Department of Pediatric Surgery, Cleveland Clinic Children's Hospital, Cleveland, OH, 44195, USA.; Department of Pediatric Surgery, Kalispell Regional Healthcare, 1333 Surgical Services Drive, Kalispell, MT, 59901, USA., Lax JE; Department of Pediatric Surgery, Cleveland Clinic Children's Hospital, Cleveland, OH, 44195, USA.; Alfa Biogene International B.V., Eemnesserweg 56, 3741 GB, Baarn, The Netherlands., Harvey J; Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute and Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 44195, USA., DiCorleto PE; Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute and Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 44195, USA.; Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 44195, USA.; Division of Research and Sponsored Programs, Kent State University, 202G Schwartz Center, Kent, OH, 44240, USA., Husni ME; Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute and Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 44195, USA.; Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 44195, USA., Chandrasekharan UM; Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute and Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 44195, USA. chandru@ccf.org., Tytell M; Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA. mtytell@wakehealth.edu.
Jazyk: angličtina
Zdroj: Cell stress & chaperones [Cell Stress Chaperones] 2018 Sep; Vol. 23 (5), pp. 1129-1135. Date of Electronic Publication: 2018 Apr 03.
DOI: 10.1007/s12192-018-0895-0
Abstrakt: Psoriasis is a chronic inflammatory skin disease with systemic manifestations and potential genetic etiology. The newest treatments utilize antibodies against one of several cytokines known to underlie the inflammatory signaling molecules that produce the skin and systemic symptoms. However, these agents must be regularly injected, and they may compromise the normal responses of the immune system. Furthermore, they do not address the causes of the abnormal immunoregulatory responses of the disease because the etiology is not yet completely understood. In this short-term treatment study, the potential anti-inflammatory activity of an alfalfa-derived Hsp70-containing skin cream (aHsp70) was tested on imiquimod (IMQ)-induced psoriasis-like lesions in wild-type mice. Treatment of the mice with the aHsp70 skin cream simultaneously with the imiquimod application mitigated the induction of psoriatic-like lesions and correlated with altered expression of various skin cytokines.
Databáze: MEDLINE
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