Bridging glycated hemoglobin with quality of life and health state; a randomized case-control study among type 2 diabetes patients.

Autor: Gillani SW; 1Department of Clinical & Hospital Pharmacy, College of Pharmacy, Taibah University, PO Box: 41411, Al-Madinah Al Munawarrah, Saudi Arabia., Ansari IA; 2Department of Pathology, College of Medicine, Taibah University, Al-Madinah Al Munawarrah, Kingdom of Saudi Arabia., Zaghloul HA; 1Department of Clinical & Hospital Pharmacy, College of Pharmacy, Taibah University, PO Box: 41411, Al-Madinah Al Munawarrah, Saudi Arabia., Abdul MIM; 1Department of Clinical & Hospital Pharmacy, College of Pharmacy, Taibah University, PO Box: 41411, Al-Madinah Al Munawarrah, Saudi Arabia., Sulaiman SAS; 3School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), Penang, Malaysia., Baig MR; 4Dubai Pharmacy College, Dubai, UAE.
Jazyk: angličtina
Zdroj: Diabetology & metabolic syndrome [Diabetol Metab Syndr] 2018 Mar 27; Vol. 10, pp. 23. Date of Electronic Publication: 2018 Mar 27 (Print Publication: 2018).
DOI: 10.1186/s13098-018-0325-6
Abstrakt: Background: The aim of this study was to explore the predictors of QOL and health state and examine the relationship with glycemic control among type 2 diabetes mellitus (T2DM) patients.
Methods: A randomized cross-sectional case-control study was conducted among n = 600 T2DM patients of Malaysia. Study population was distributed into three groups as: controls: patients with HbA1c ≤ 7 (n = 199), cases arm 1: with HbA1c 7-7.9 (n = 204) and cases arm 2 (n = 197): with HbA1c ≥ 8 consecutively last 3 times.
Results: Participants with diabetes history > 10 years exhibits higher mean QOL score among all the three groups. In contrast mean health status score significantly ( p  < 0.001) reduced with the exposure duration of diabetes both within and intergroup assessment that participants with poor glycemic control (arm 2) had significantly higher mean QOL score with knowledge and self-care dimensions as compared to others, however mean health state scores were significantly ( p  < 0.001) lower in all assessment dimensions as compared to controls. The F test of significance showed that demographic and clinical parameters were strong predictors of QOL, whereas self-care activities, comorbidities, ability of positive management and BMI were significant predictors to health state for consistent glycemic control (controls) as compared to poor glycemic control (arm 2) participants.
Conclusion: This study suggested that poor glycemic index reported low self-care behavior, increase barriers to daily living activities and poor ability to manage diabetes positively, which cause poor QOL and decrease health state.
Databáze: MEDLINE
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