Identification of immunologic and clinical characteristics that predict inflammatory response to C. Novyi-NT bacteriolytic immunotherapy.

Autor: DeClue AE; Department of Veterinary Medicine and Surgery, Comparative Internal Medicine Laboratory, University of Missouri, College of Veterinary Medicine, 900 E. Campus Dr, Columbia, MO, 65203, USA. decluea@misssouri.edu., Axiak-Bechtel SM; Department of Veterinary Medicine and Surgery, Comparative Oncology Radiobiology and Epigenetics Laboratory, University of Missouri, College of Veterinary Medicine, 900 E. Campus Dr, Columbia, MO, 65203, USA., Zhang Y; Department of Veterinary Medicine and Surgery, Comparative Internal Medicine Laboratory, University of Missouri, College of Veterinary Medicine, 900 E. Campus Dr, Columbia, MO, 65203, USA., Saha S; Biomed Valley Discoveries, 4435 Main Street, Suite 550, Kansas City, MO, 64111, USA., Zhang L; Biomed Valley Discoveries, 4435 Main Street, Suite 550, Kansas City, MO, 64111, USA., Tung DD; Biomed Valley Discoveries, 4435 Main Street, Suite 550, Kansas City, MO, 64111, USA., Bryan JN; Department of Veterinary Medicine and Surgery, Comparative Oncology Radiobiology and Epigenetics Laboratory, University of Missouri, College of Veterinary Medicine, 900 E. Campus Dr, Columbia, MO, 65203, USA.
Jazyk: angličtina
Zdroj: BMC veterinary research [BMC Vet Res] 2018 Apr 02; Vol. 14 (1), pp. 119. Date of Electronic Publication: 2018 Apr 02.
DOI: 10.1186/s12917-018-1424-1
Abstrakt: Background: Clostridium novyi-NT (CNV-NT), has shown promise as a bacterolytic therapy for solid tumors in mouse models and in dogs with naturally developing neoplasia. Factors that impact the immunologic response to therapy are largely unknown. The goal of this pilot study was to determine if plasma immune biomarkers, immune cell function, peripheral blood cytological composition and tumor characteristics including evaluation of a PET imaging surrogate of tumor tissue hypoxia could predict which dogs with naturally developing naïve neoplasia would develop an inflammatory response to CNV-NT.
Results: Dogs that developed an inflammatory response to CNV-NT had a higher heart rate, larger gross tumor volume, greater tumor [ 64 Cu]ATSM SUV Max , increased constitutive leukocyte IL-10 production, more robust NK cell-like function and greater peripheral blood lymphocyte counts compared to dogs that did not develop an inflammatory response to CNV-NT. Of these, unstimulated leukocyte IL-10 production, heart rate, and gross tumor volume appeared to be the best predictors of which dogs will develop an inflammatory response to CNV-NT.
Conclusions: Development of inflammation in response to CNV-NT is best predicted by pretreatment unstimulated leukocyte IL-10 production, heart rate, and gross tumor volume.
Databáze: MEDLINE
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