Toxicity of silver nanoparticles, multiwalled carbon nanotubes, and dendrimers assessed with multicellular organism Caenorhabditis elegans.

Autor: Walczynska M; a Division of Biophysics, Institute of Materials Science and Engineering , Lodz University of Technology , Lodz , Poland., Jakubowski W; a Division of Biophysics, Institute of Materials Science and Engineering , Lodz University of Technology , Lodz , Poland., Wasiak T; b Laboratory of Molecular and Nanostructural Biophysics , BioNanoPark Ltd , Lodz , Poland., Kadziola K; b Laboratory of Molecular and Nanostructural Biophysics , BioNanoPark Ltd , Lodz , Poland., Bartoszek N; b Laboratory of Molecular and Nanostructural Biophysics , BioNanoPark Ltd , Lodz , Poland., Kotarba S; b Laboratory of Molecular and Nanostructural Biophysics , BioNanoPark Ltd , Lodz , Poland., Siatkowska M; a Division of Biophysics, Institute of Materials Science and Engineering , Lodz University of Technology , Lodz , Poland.; b Laboratory of Molecular and Nanostructural Biophysics , BioNanoPark Ltd , Lodz , Poland., Komorowski P; a Division of Biophysics, Institute of Materials Science and Engineering , Lodz University of Technology , Lodz , Poland.; b Laboratory of Molecular and Nanostructural Biophysics , BioNanoPark Ltd , Lodz , Poland., Walkowiak B; a Division of Biophysics, Institute of Materials Science and Engineering , Lodz University of Technology , Lodz , Poland.; b Laboratory of Molecular and Nanostructural Biophysics , BioNanoPark Ltd , Lodz , Poland.
Jazyk: angličtina
Zdroj: Toxicology mechanisms and methods [Toxicol Mech Methods] 2018 Jul; Vol. 28 (6), pp. 432-439. Date of Electronic Publication: 2018 Apr 20.
DOI: 10.1080/15376516.2018.1449277
Abstrakt: Nematode Caenorhabditis elegans (C. elegans) was used to investigate the impact of silver nanoparticles (SNP), multiwalled carbon nanotubes (MWCNT), and polyamidoamine dendrimers (PAMAM) used in concentration of 10 10 particle/mL. Population-based observations and gene expression analysis were employed in this study. SNP and PAMAM caused decrease in the number of live nematodes and their body length, but MWCNT did not affect the population of nematodes. Gene expression analysis revealed significant changes caused by the presence of all studied nanomaterials, and the results strongly suggest a specific metabolic response of the nematode organism to exposure to various nanomaterials. It was shown that C. elegans is a very sensitive organism capable to respond specifically to the exposure to some nanomaterials and therefore could be considered as a possible biosensor for early warning of presence of some nanoparticles.
Databáze: MEDLINE
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