Lack of evidence of association between IFNG and IL28B polymorphisms and QuantiFERON-CMV test results in seropositive transplant patients.

Autor: Aguado R; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Reina Sofía University Hospital/University of Cordoba, (REIPI RD12/0015 and REIPI RD16/0016/0008), Cordoba, Spain., Páez-Vega A; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Reina Sofía University Hospital/University of Cordoba, (REIPI RD12/0015 and REIPI RD16/0016/0008), Cordoba, Spain., Agüera ML; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Reina Sofía University Hospital/University of Cordoba, (REIPI RD12/0015 and REIPI RD16/0016/0008), Cordoba, Spain; Department of Nephrology, Reina Sofia Hospital, (REDinREN RD16/0009/0034), Cordoba, Spain., Montejo M; Infectious Diseases Unit, Cruces Hospital, Bilbao, Spain., Guirado L; Department of Nephrology, Puigvert Fundació, (REDinREN RD16/0009/0019), Barcelona, Spain., Fortún J; Infectious Diseases Unit, Ramón y Cajal Hospital, (REIPI RD16/0016/0011), Madrid, Spain., Suárez-Benjumea A; Department of Nephrology, Virgen del Rocío University Hospital, Sevilla, Spain., Len O; Infectious Diseases Unit, Hospital Universitari Vall d'Hebron, (REIPI RD16/0016/0003), Barcelona, Spain., Fariñas MC; Infectious Diseases Unit, Marqués de Valdecilla Hospital, University of Cantabria, IDIVAL, (REIPI RD16/0016/0007), Santander, Spain., de Gracia C; Department of Nephrology, Virgen de las Nieves Hospital, Granada, Spain., Hernández D; Department of Nephrology, Carlos Haya Regional University Hospital, University of Malaga, IBIMA, (REDinREN RD16/0009/0006), Malaga, Spain., Cobos-Ceballos MJ; Department of Pneumology, Reina Sofía Hospital, Cordoba, Spain., Torre-Cisneros J; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Reina Sofía University Hospital/University of Cordoba, (REIPI RD12/0015 and REIPI RD16/0016/0008), Cordoba, Spain; Infectious Diseases Unit, Reina Sofía Hospital, Cordoba, Spain. Electronic address: julian.torre.sspa@juntadeandalucia.es., Cantisán S; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Reina Sofía University Hospital/University of Cordoba, (REIPI RD12/0015 and REIPI RD16/0016/0008), Cordoba, Spain.
Jazyk: angličtina
Zdroj: Human immunology [Hum Immunol] 2018 Jun; Vol. 79 (6), pp. 499-505. Date of Electronic Publication: 2018 Mar 29.
DOI: 10.1016/j.humimm.2018.03.009
Abstrakt: The aim of this study was to analyze the relationship between the IFNG +874 T/A and IL28B (rs12979860) C/T polymorphisms and the secretion of IFNG by CD8+ T cells after stimulation with cytomegalovirus (CMV) peptides, measured using QuantiFERON-CMV (QF-CMV) assay. A total of 184 CMV-seropositive solid organ transplant patients (108 kidney, 68 liver and 8 lung) were recruited. Of them, 151 patients were QF-CMV Reactive (IFNG ≥ 0.2 UI/mL) and 33 were Non-reactive. Genotype frequencies in the study population were TT (26.6%), AT (50.0%) and AA (23.4%) for IFNG +874 and CC (52.7%), CT (39.1%) and TT (8.2%) for IL28B (rs12979860). These frequencies did not significantly differ between QF-CMV Reactive and Non-reactive patients. Nor were any significant differences observed in the quantitative IFNG level among the genotypes in either the IFNG or the IL28 genes. When we analyzed whether these polymorphisms had any impact on the risk of CMV replication after transplantation, the adjusted analysis showed no association. In summary, our results showed that IFNG +874 T/A and IL28B (rs12979860) C/T polymorphisms are not associated with the IFNG response to CMV measured by the QuantiFERON-CMV assay, although these results should be confirmed with a higher number of patients.
(Copyright © 2018. Published by Elsevier Inc.)
Databáze: MEDLINE
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