| Autor: |
Hodges KB; Department of Pathology & Laboratory Medicine, University of Kentucky, Lexington, Kentucky., Bachert E; Department of Pathology & Laboratory Medicine, University of Kentucky, Lexington, Kentucky., Cheng L; Departments of Pathology, Indiana University School of Medicine, Indianapolis, USA; Department of Urology, Indiana University School of Medicine, Indianapolis, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Critical reviews in oncogenesis [Crit Rev Oncog] 2017; Vol. 22 (5-6), pp. 253-269. |
| DOI: |
10.1615/CritRevOncog.2017020500 |
| Abstrakt: |
Prostate cancer (PCa) is the second most frequently diagnosed cancer among men worldwide. Given the biological heterogeneity in localized PCa and its variable clinical course, a personalized approach to patient risk stratification and management is needed. A variety of high-throughput technologies, such as next-generation sequencing, transcriptomic, epigenetic, and metabolomic modalities have led to an improved understanding of the genomic basis of PCa and the identification of PCa biomarkers. Novel genomic approaches offer additional information to improve clinical decision making. The goal of this report is to review the use of currently available molecular biomarkers in the diagnosis and prognostication of PCa outcome. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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