Assessing the risk of epidemic dropsy from black salve use.

Autor: Croaker A; Southern Cross Plant Science, Southern Cross University, Lismore, NSW, Australia.; Wesley Medical Research Institute, Wesley Hospital, Auchenflower, QLD, Australia.; Quality Use of Medicines Network, Queensland, Australia., King GJ; Southern Cross Plant Science, Southern Cross University, Lismore, NSW, Australia., Pyne JH; School of Medicine, University of Queensland, St Lucia, QLD, Australia., Anoopkumar-Dukie S; Quality Use of Medicines Network, Queensland, Australia.; School of Pharmacy and Pharmacology, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia., Liu L; Southern Cross Plant Science, Southern Cross University, Lismore, NSW, Australia.
Jazyk: angličtina
Zdroj: Journal of applied toxicology : JAT [J Appl Toxicol] 2018 Oct; Vol. 38 (10), pp. 1274-1281. Date of Electronic Publication: 2018 Mar 30.
DOI: 10.1002/jat.3619
Abstrakt: Epidemic dropsy is a potentially life-threatening condition resulting from the ingestion of argemone oil derived from the seeds of Argemone mexicana Linn. Exposure to argemone oil is usually inadvertent, arising from mustard cooking oil adulteration. Sanguinarine, an alkaloid present in argemone oil, has been postulated as a causative agent with the severity of epidemic dropsy correlating with plasma sanguinarine levels. Cases of epidemic dropsy have also been reported following the topical application of argemone containing massage oil. Black salve, a topical skin cancer therapy also contains sanguinarine, but at significantly higher concentrations than that reported for contaminated massage oil. Although not reported to date, a theoretical risk therefore exists of black salve inducing epidemic dropsy. This literature review explores the presentation and pathophysiology of epidemic dropsy and assesses the risk of it being induced by black salve.
(Copyright © 2018 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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