The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells.

Autor: Alferez DG; Breast Biology Group, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine, and Health, Manchester Cancer Research Centre, Wilmslow Road, Manchester, M20 4GJ UK., Simões BM; Breast Biology Group, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine, and Health, Manchester Cancer Research Centre, Wilmslow Road, Manchester, M20 4GJ UK., Howell SJ; Breast Biology Group, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine, and Health, Manchester Cancer Research Centre, Wilmslow Road, Manchester, M20 4GJ UK.; Department of Medical Oncology, The University of Manchester, The Christie NHS Foundation Trust, Manchester, M20 4BX UK., Clarke RB; Breast Biology Group, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine, and Health, Manchester Cancer Research Centre, Wilmslow Road, Manchester, M20 4GJ UK.
Jazyk: angličtina
Zdroj: Current stem cell reports [Curr Stem Cell Rep] 2018; Vol. 4 (1), pp. 81-94. Date of Electronic Publication: 2018 Mar 13.
DOI: 10.1007/s40778-018-0114-z
Abstrakt: Purpose of Review: This review will discuss how the steroid hormones, estrogen and progesterone, as well as treatments that target steroid receptors, can regulate cancer stem cell (CSC) activity. The CSC theory proposes a hierarchical organization in tumors where at its apex lies a subpopulation of cancer cells endowed with self-renewal and differentiation capacity.
Recent Findings: In breast cancer (BC), CSCs have been suggested to play a key role in tumor maintenance, disease progression, and the formation of metastases. In preclinical models of BC, only a few CSCs are required sustain tumor re-growth, especially after conventional anti-endocrine treatments. CSCs include therapy-resistant clones that survive standard of care treatments like chemotherapy, irradiation, and hormonal therapy.
Summary: The relevance of hormones for both normal mammary gland and BC development is well described, but it was only recently that the activities of hormones on CSCs have been investigated, opening new directions for future BC treatments and CSCs.
Competing Interests: Compliance with Ethical StandardsDr. Denis G. Alferez, Dr. Bruno M. Simões, Dr. Sacha J. Howell, and Dr. Robert B. Clarke declare that they have no conflict of interest.This article does not contain any studies with human or animal subjects performed by any of the authors.
Databáze: MEDLINE
Externí odkaz: