Predictive Factors for Local Control and Survival in Patients with Cancer of Unknown Primary (CUP) Irradiated for Cerebral Metastases.

Autor:	Rades D; Department of Radiation Oncology, University of Lübeck, Lübeck, Germany rades.dirk@gmx.net.; Faculty of Medicine, Hanoi Medical University, Hanoi, Vietnam., Dziggel L; Department of Radiation Oncology, University of Lübeck, Lübeck, Germany., Janssen S; Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.; Private Practice of Radiation Oncology, Hannover, Germany., Khoa MT; Faculty of Medicine, Hanoi Medical University, Hanoi, Vietnam.; Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam., Duong VN; Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam., Khiem VH; Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam., Gebauer N; Department of Hematology and Medical Oncology, University of Lübeck, Lübeck, Germany., Bartscht T; Department of Hematology and Medical Oncology, University of Lübeck, Lübeck, Germany., Schild SE; Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.
Jazyk:	angličtina
Zdroj:	Anticancer research [Anticancer Res] 2018 Apr; Vol. 38 (4), pp. 2415-2418.
DOI:	10.21873/anticanres.12492
Abstrakt:	Background/aim: To identify predictors of local control and survival after whole-brain irradiation (WBI) for cerebral metastases from cancer of unknown primary (CUP). Patients and Methods: In 140 patients receiving WBI alone or following resection, seven factors were investigated including treatment approach, WBI-regimen, age, gender, Eastern Cooperative Oncology Group (ECOG) performance score, number of cerebral lesions and extra-cerebral metastases. Results: On univariate analysis, resection plus WBI and boost (p=0.002), ECOG 0-1 (p<0.001) and a single lesion (p<0.001) were positively associated with local control. On Cox regression, ECOG-score remained significant (p=0.002). On univariate analysis of survival, surgery plus WBI and boost (p=0.009), ECOG 0-1 (p<0.001), a single lesion (p=0.024) and no extra-cerebral metastases (p<0.001) were associated with better outcomes. On Cox regression, ECOG-score (p<0.001) and extra-cerebral lesions (p<0.001) were significant. Conclusion: Significant predictors of local control and survival were identified that contribute to treatment personalization and design of prospective trials in patients with cerebral metastases from CUP. (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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