Destabilizing mutations encode nongenetic variation that drives evolutionary innovation.

Autor: Petrie KL; Division of Biological Sciences, University of California (UC) San Diego, La Jolla, CA 92093, USA. kpetrie@ucsd.edu jrmeyer@ucsd.edu.; Earth-Life Science Institute (ELSI), Tokyo Institute of Technology, Tokyo, Japan., Palmer ND; Division of Biological Sciences, University of California (UC) San Diego, La Jolla, CA 92093, USA., Johnson DT; Division of Biological Sciences, University of California (UC) San Diego, La Jolla, CA 92093, USA., Medina SJ; Division of Biological Sciences, University of California (UC) San Diego, La Jolla, CA 92093, USA., Yan SJ; Division of Biological Sciences, University of California (UC) San Diego, La Jolla, CA 92093, USA., Li V; Division of Biological Sciences, University of California (UC) San Diego, La Jolla, CA 92093, USA., Burmeister AR; Department of Ecology and Evolution, Yale University, New Haven, CT 06520, USA., Meyer JR; Division of Biological Sciences, University of California (UC) San Diego, La Jolla, CA 92093, USA. kpetrie@ucsd.edu jrmeyer@ucsd.edu.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2018 Mar 30; Vol. 359 (6383), pp. 1542-1545.
DOI: 10.1126/science.aar1954
Abstrakt: Evolutionary innovations are often achieved by repurposing existing genes to perform new functions; however, the mechanisms enabling the transition from old to new remain controversial. We identified mutations in bacteriophage λ's host-recognition gene J that confer enhanced adsorption to λ's native receptor, LamB, and the ability to access a new receptor, OmpF. The mutations destabilize λ particles and cause conformational bistability of J, which yields progeny of multiple phenotypic forms, each proficient at different receptors. This work provides an example of how nongenetic protein variation can catalyze an evolutionary innovation. We propose that cases where a single genotype can manifest as multiple phenotypes may be more common than previously expected and offer a general mechanism for evolutionary innovation.
(Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
Databáze: MEDLINE
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