Effects of Chronic Lymphocytic Thyroiditis on the Clinicopathological Features of Papillary Thyroid Cancer.

Autor:	Babli S; Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Québec, Canada.; Department of Endocrinology and Diabetes, Prince Sultan Military Medical City, Riyadh, Saudi Arabia., Payne RJ; Department of Otolaryngology, Royal Victoria Hospital, McGill University, Montreal, Québec, Canada., Mitmaker E; Department of Surgery, Montreal General Hospital, McGill University, Montreal, Québec, Canada., Rivera J; Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Québec, Canada.
Jazyk:	angličtina
Zdroj:	European thyroid journal [Eur Thyroid J] 2018 Mar; Vol. 7 (2), pp. 95-101. Date of Electronic Publication: 2018 Jan 10.
DOI:	10.1159/000486367
Abstrakt:	Background: The effects of chronic lymphocytic thyroiditis (CLT) on the presentation and outcome of papillary thyroid carcinoma (PTC) have long been a topic of controversy. Objective: To evaluate the effect of coexistent CLT on the clinicopathological features of PTC. Design: Retrospective study. Patients: All patients with PTC who had been followed by the 2 co-investigators (Juan Rivera and Richard J. Payne) between 2006 and 2011 were included. Results: CLT was present in 35% (166) of the included patients and was associated with a higher proportion of patients with TNM stage I ( p = 0.027) and fewer patients with persistent disease ( p = 0.014) in comparison with the PTC-only group. Analysis of the data based on age (<45 or >45 years) revealed that in the older group, the presence of CLT was associated with fewer patients with persistent disease ( p = 0.03) and capsular invasion ( p = 0.05). However, in patients <45 years of age, the presence of CLT was associated with more capsular invasion ( p = 0.003) and extrathyroidal extension ( p = 0.004) compared with the PTC-only group. Conclusions: CLT in patients with PTC was associated with lower-stage disease and less disease persistence in patients >45 years of age. In patients <45 years, the presence of CLT appeared to be associated with unfavorable pathological features.
Databáze:	MEDLINE
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