Approaches in studying the pharmacology of Chinese Medicine formulas: bottom-up, top-down-and meeting in the middle.

Autor: Huang T; 1Institute of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, Room 307, Jockey Club School of Chinese Medicine, 7 Baptist University Road, Kowloon, Hong Kong, Hong Kong SAR China., Zhong LLD; 1Institute of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, Room 307, Jockey Club School of Chinese Medicine, 7 Baptist University Road, Kowloon, Hong Kong, Hong Kong SAR China.; 2Hong Kong Chinese Medicine Clinical Study Centre, Hong Kong Baptist University, Room 307, Jockey Club School of Chinese Medicine, 7 Baptist University Road, Kowloon, Hong Kong, Hong Kong SAR China., Lin CY; 1Institute of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, Room 307, Jockey Club School of Chinese Medicine, 7 Baptist University Road, Kowloon, Hong Kong, Hong Kong SAR China.; 3YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, Kunming, 650500 China., Zhao L; 1Institute of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, Room 307, Jockey Club School of Chinese Medicine, 7 Baptist University Road, Kowloon, Hong Kong, Hong Kong SAR China., Ning ZW; 1Institute of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, Room 307, Jockey Club School of Chinese Medicine, 7 Baptist University Road, Kowloon, Hong Kong, Hong Kong SAR China., Hu DD; 1Institute of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, Room 307, Jockey Club School of Chinese Medicine, 7 Baptist University Road, Kowloon, Hong Kong, Hong Kong SAR China., Zhang M; 1Institute of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, Room 307, Jockey Club School of Chinese Medicine, 7 Baptist University Road, Kowloon, Hong Kong, Hong Kong SAR China.; 4Guangzhou Research Institute of Snake Venom, Guangzhou Medical University, Guangzhou, 510000 China., Tian K; 1Institute of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, Room 307, Jockey Club School of Chinese Medicine, 7 Baptist University Road, Kowloon, Hong Kong, Hong Kong SAR China., Cheng CW; 2Hong Kong Chinese Medicine Clinical Study Centre, Hong Kong Baptist University, Room 307, Jockey Club School of Chinese Medicine, 7 Baptist University Road, Kowloon, Hong Kong, Hong Kong SAR China., Bian ZX; 1Institute of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, Room 307, Jockey Club School of Chinese Medicine, 7 Baptist University Road, Kowloon, Hong Kong, Hong Kong SAR China.; 2Hong Kong Chinese Medicine Clinical Study Centre, Hong Kong Baptist University, Room 307, Jockey Club School of Chinese Medicine, 7 Baptist University Road, Kowloon, Hong Kong, Hong Kong SAR China.
Jazyk: angličtina
Zdroj: Chinese medicine [Chin Med] 2018 Mar 21; Vol. 13, pp. 15. Date of Electronic Publication: 2018 Mar 21 (Print Publication: 2018).
DOI: 10.1186/s13020-018-0170-4
Abstrakt: Investigating the pharmacology is key to the modernization of Chinese Medicine (CM) formulas. However, identifying which are the active compound(s) of CM formulas, which biological entities they target, and through which signaling pathway(s) they act to modify disease symptoms, are still difficult tasks for researchers, even when equipped with an arsenal of advanced modern technologies. Multiple approaches, including network pharmacology, pharmaco-genomics, -proteomics, and -metabolomics, have been developed to study the pharmacology of CM formulas. They fall into two general categories in terms of how they tackle a problem: bottom-up and top-down. In this article, we compared these two different approaches in several dimensions by using the case of MaZiRenWan (MZRW, also known as Hemp Seed Pill), a CM herbal formula for functional constipation. Multiple hypotheses are easy to be proposed in the bottom-up approach (e.g. network pharmacology); but these hypotheses are usually false positives and hard to be tested. In contrast, it is hard to suggest hypotheses in the top-down approach (e.g. pharmacometabolomics); however, once a hypothesis is proposed, it is much easier to be tested. Merging of these two approaches could results in a powerful approach, which could be the new paradigm for the pharmacological study of CM formulas.
Databáze: MEDLINE
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