Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin.

Autor:	Umerska A; Université de Lorraine, CITHEFOR, F-54000 Nancy, France. anita.umerska@univ-lorraine.fr., Gaucher C; Université de Lorraine, CITHEFOR, F-54000 Nancy, France. caroline.gaucher@univ-lorraine.fr., Oyarzun-Ampuero F; Departamento de Ciencias y Tecnología Farmacéuticas, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, 758-0150 Santiago, Chile., Fries-Raeth I; Université de Lorraine, CITHEFOR, F-54000 Nancy, France. Isabelle.Raeth@univ-lorraine.fr., Colin F; Université de Lorraine, CITHEFOR, F-54000 Nancy, France. florence.colin88@gmail.com., Villamizar-Sarmiento MG; Departamento de Ciencias y Tecnología Farmacéuticas, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, 758-0150 Santiago, Chile., Maincent P; Université de Lorraine, CITHEFOR, F-54000 Nancy, France. philippe.maincent@univ-lorraine.fr., Sapin-Minet A; Université de Lorraine, CITHEFOR, F-54000 Nancy, France.
Jazyk:	angličtina
Zdroj:	Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2018 Mar 24; Vol. 7 (4). Date of Electronic Publication: 2018 Mar 24.
DOI:	10.3390/antiox7040046
Abstrakt:	Despite the promising biological and antioxidant properties of curcumin, its medical applications are limited due to poor solubility in water and low bioavailability. Polymeric nanoparticles (NPs) adapted to oral delivery may overcome these drawbacks. Properties such as particle size, zeta potential, morphology and encapsulation efficiency were assessed. Then, the possibility of storing these NPs in a solid-state form obtained by freeze-drying, in vitro curcumin dissolution and cytocompatibility towards intestinal cells were evaluated. Curcumin-loaded Eudragit ® RLPO (ERL) NPs showed smaller particle diameters (245 ± 2 nm) and better redispersibility after freeze-drying than either poly(lactic- co -glycolic acid) (PLGA) or polycaprolactone (PCL) NPs. The former NPs showed lower curcumin encapsulation efficiency (62%) than either PLGA or PCL NPs (90% and 99%, respectively). Nevertheless, ERL NPs showed rapid curcumin release with 91 ± 5% released over 1 h. The three curcumin-loaded NPs proposed in this work were also compatible with intestinal cells. Overall, ERL NPs are the most promising vehicles for increasing the oral bioavailability of curcumin. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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