The kinetoplastid-infecting Bodo saltans virus (BsV), a window into the most abundant giant viruses in the sea.

Autor:	Deeg CM; Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada., Chow CT; Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, Canada., Suttle CA; Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.; Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, Canada.; Department of Botany, University of British Columbia, Vancouver, Canada.; Institute for the Oceans and Fisheries, University of British Columbia, Vancouver, Canada.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2018 Mar 27; Vol. 7. Date of Electronic Publication: 2018 Mar 27.
DOI:	10.7554/eLife.33014
Abstrakt:	Giant viruses are ecologically important players in aquatic ecosystems that have challenged concepts of what constitutes a virus. Herein, we present the giant Bodo saltans virus (BsV), the first characterized representative of the most abundant group of giant viruses in ocean metagenomes, and the first isolate of a klosneuvirus, a subgroup of the Mimiviridae proposed from metagenomic data. BsV infects an ecologically important microzooplankton, the kinetoplastid Bodo saltans . Its 1.39 Mb genome encodes 1227 predicted ORFs, including a complex replication machinery. Yet, much of its translational apparatus has been lost, including all tRNAs. Essential genes are invaded by homing endonuclease-encoding self-splicing introns that may defend against competing viruses. Putative anti-host factors show extensive gene duplication via a genomic accordion indicating an ongoing evolutionary arms race and highlighting the rapid evolution and genomic plasticity that has led to genome gigantism and the enigma that is giant viruses. Competing Interests: CD, CC, CS No competing interests declared (© 2018, Deeg et al.)
Databáze:	MEDLINE
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