Peripheral Blood Regulatory T Cells Are Diminished in Kidney Transplant Patients With Chronic Allograft Nephropathy.

Autor: Carmona-Escamilla MA; Programa de posgrado en Ciencias Médicas, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, México., Queipo G; Departamento de Genética Humana, Hospital General de México Dr. Eduardo Liceaga, México City, México; Programa de posgrado en Ciencias Biológicas, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, México; Departamento de Trasplante de Órganos, Hospital General de México Dr. Eduardo Liceaga, México City, México; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, México., García-Mosqueda LA; Programa de posgrado en Ciencias Biológicas, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, México., García-Covarrubias L; Programa de posgrado en Ciencias Biológicas, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, México., Fonseca-Sánchez MA; Departamento de Genética Humana, Hospital General de México Dr. Eduardo Liceaga, México City, México., Villanueva-Ortega E; Departamento de Genética Humana, Hospital General de México Dr. Eduardo Liceaga, México City, México., Prieto P; Departamento de Trasplante de Órganos, Hospital General de México Dr. Eduardo Liceaga, México City, México., Lascurain R; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, México; Hospital Nacional Homeopático, Secretaría de Salud, Mexico City, Mexico. Electronic address: rlascurainl@yahoo.com.mx.
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2018 Mar; Vol. 50 (2), pp. 444-448.
DOI: 10.1016/j.transproceed.2018.01.001
Abstrakt: Background: Our aim in this study was to assess peripheral blood CD4 + CD25 + FOXP3 + regulatory T cell (Treg) levels in patients with chronic allograft nephropathy (CAN) 1 year after kidney transplantation.
Methods: Twelve renal transplant patients with an initial onset of CAN, 12 patients with chronic kidney disease (CKD) stage G5 on dialysis, and 13 healthy control individuals were evaluated regarding the proportion of Tregs in their peripheral blood via flow cytometry.
Results: The renal transplant patients with CAN had a significantly lower proportion of Tregs than the hemodialysis CKD patients and healthy controls (P < .0001). In contrast, the hemodialysis CKD patients showed higher levels of Tregs than the renal transplant patients with CAN and the healthy controls (P < .0001).
Conclusion: The high level of peripheral blood Tregs in the hemodialysis CKD patients suggests a chronic inflammatory state. However, the low frequency of Tregs in the peripheral blood from the renal transplant patients with CAN suggests an unfavorable prognosis for allograft immune tolerance.
(Copyright © 2018. Published by Elsevier Inc.)
Databáze: MEDLINE
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