Seroepidemiology of helminths and the association with severe malaria among infants and young children in Tanzania.

Autor: Kwan JL; Epidemiology Unit, Laboratory of Clinical Infectious Disease, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States of America., Seitz AE; Epidemiology Unit, Laboratory of Clinical Infectious Disease, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States of America., Fried M; Laboratory of Malaria Immunology and Vaccinology, DIR, NIAID, NIH, Bethesda, MD, United States of America., Lee KL; Laboratory of Malaria Immunology and Vaccinology, DIR, NIAID, NIH, Bethesda, MD, United States of America., Metenou S; Laboratory of Parasitic Diseases, DIR, NIAID, NIH, Bethesda, MD, United States of America., Morrison R; Seattle Biomedical Research Institute, Seattle, WA, United States of America., Kabyemela E; Seattle Biomedical Research Institute, Seattle, WA, United States of America., Nutman TB; Laboratory of Parasitic Diseases, DIR, NIAID, NIH, Bethesda, MD, United States of America., Prevots DR; Epidemiology Unit, Laboratory of Clinical Infectious Disease, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States of America., Duffy PE; Laboratory of Malaria Immunology and Vaccinology, DIR, NIAID, NIH, Bethesda, MD, United States of America.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2018 Mar 26; Vol. 12 (3), pp. e0006345. Date of Electronic Publication: 2018 Mar 26 (Print Publication: 2018).
DOI: 10.1371/journal.pntd.0006345
Abstrakt: The disease burden of Wuchereria bancrofti and Plasmodium falciparum malaria is high, particularly in Africa, and co-infection is common. However, the effects of filarial infection on the risk of severe malaria are unknown. We used the remaining serum samples from a large cohort study in Muheza, Tanzania to describe vector-borne filarial sero-reactivity among young children and to identify associations between exposure to filarial parasites and subsequent severe malaria infections. We identified positive filarial antibody responses (as well as positive antibody responses to Strongyloides stercoralis) among infants as young as six months. In addition, we found a significant association between filarial seropositivity at six months of age and subsequent severe malaria. Specifically, infants who developed severe malaria by one year of age were 3.9 times more likely (OR = 3.9, 95% CI: 1.2, 13.0) to have been seropositive for filarial antigen at six months of age compared with infants who did not develop severe malaria.
Databáze: MEDLINE
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