| Autor: |
Karpenko MN; Institute of Experimental Medicine, St. Petersburg, Russia.; St. Petersburg National Research University of Information Technologies, Mechanics, and Optics (ITMO University), St. Petersburg, Russia.; Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia., Ilyicheva EY; Institute of Experimental Medicine, St. Petersburg, Russia. ilichevaey@gmail.com.; St. Petersburg National Research University of Information Technologies, Mechanics, and Optics (ITMO University), St. Petersburg, Russia. ilichevaey@gmail.com., Muruzheva ZM; Institute of Experimental Medicine, St. Petersburg, Russia., Milyukhina IV; Institute of Experimental Medicine, St. Petersburg, Russia., Orlov YA; St. Petersburg National Research University of Information Technologies, Mechanics, and Optics (ITMO University), St. Petersburg, Russia., Puchkova LV; Institute of Experimental Medicine, St. Petersburg, Russia.; St. Petersburg National Research University of Information Technologies, Mechanics, and Optics (ITMO University), St. Petersburg, Russia.; Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia. |
| Abstrakt: |
Serum concentration of copper, immunoreactive polypeptides of ceruloplasmin and its oxidase activity, and the number of copper atoms per ceruloplasmin molecule were decreased in patients with Parkinson's disease in comparison with the corresponding parameters in age-matched healthy individuals, but the ratio of apoceruloplasmin to holoceruloplasmin in patients with Parkinson's disease was similar in both groups. Treatment of blood serum with Helex 100, a high-affinity copper chelator, revealed reduced content of labile copper atoms per ceruloplasmin molecule in patients with Parkinson's disease in comparison with that in healthy controls. The mechanism underlying impaired metabolic incorporation of labile copper atoms into CP molecule is discussed as a possible cause of copper dyshomeostasis associated with Parkinson's disease. |
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