Is the Use of Dexamethasone Effective in Controlling Pain Associated with Symptomatic Irreversible Pulpitis? A Systematic Review.

Autor:	Nogueira BML; School of Dentistry, Institute of Health Sciences, Federal University of Pará, Belém, Pará, Brazil. Electronic address: bre_nog@hotmail.com., Silva LG; School of Dentistry, Institute of Health Sciences, Federal University of Pará, Belém, Pará, Brazil., Mesquita CRM; University of Brasília, Brasília, Brazil., Menezes SAF; University Center of Pará, Belém, Pará, Brazil., Menezes TOA; School of Dentistry, Institute of Health Sciences, Federal University of Pará, Belém, Pará, Brazil., Faria AGM; School of Dentistry, Institute of Health Sciences, Federal University of Pará, Belém, Pará, Brazil., Porpino MTM; University Center of Pará, Belém, Pará, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of endodontics [J Endod] 2018 May; Vol. 44 (5), pp. 703-710. Date of Electronic Publication: 2018 Mar 20.
DOI:	10.1016/j.joen.2018.02.006
Abstrakt:	Introduction: Endodontic pain is a symptom of pulpal and/or periapical inflammation. One strategy for pain reduction is using medications, such as dexamethasone. A definitive protocol for preventing and controlling pain caused by irreversible pulpitis during endodontic treatment has not yet been established. This is a systematic review to answer the following question: is the use of dexamethasone effective in controlling pain associated with symptomatic irreversible pulpitis? Methods: This study was registered in the PROSPERO database (CRD42017058704), and Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement recommendations were followed. MEDLINE, Scopus, ScienceDirect, Web of Science, Latin American Caribbean Health Sciences Literature, Cochrane Library, and Google Scholar databases were used in our research. No restrictions were applied to dates or language of publication. All records identified electronically were organized and evaluated by 2 independent authors, and, in case of doubt, a third author made the decision. The Cochrane Collaboration tool was used. The data were analyzed with RevMan 5 software (The Cochrane Collaboration, Copenhagen, Denmark), and data from eligible studies were dichotomous (with and without pain). Results: A total of 4825 studies were identified. After screening, 523 studies were selected, and, after careful evaluation, only 5 articles remained. All meta-analyses revealed a global effect (P < .05, P < .05, and P < .05), which means that 4 mg dexamethasone helps relieve pain, sometimes for up to 8, 12, and 24 hours. Conclusions: The pain felt by patients diagnosed with symptomatic irreversible pulpitis may be alleviated by administering 4 mg dexamethasone either by mouth or through intraligamentary and mainly supraperiosteal injections into the root canal for up to 24 hours. (Copyright © 2018 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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