Comparative Molluscicidal and Schistosomicidal Potentiality of Two Solanum Species and Its Isolated Glycoalkaloids.

Autor: Alsherbiny MA; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt., El Badawy SA; Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Elbedewy H; Institute for Biomolecular Research,, Faculty of Chemistry and Biology, Hochschule Fresenius University of Applied Sciences, 65510 Idstein, Germany., Ezzat SM; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Elsakhawy FS; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Abdel-Kawy MA; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Pharmacognosy research [Pharmacognosy Res] 2018 Jan-Mar; Vol. 10 (1), pp. 113-117.
DOI: 10.4103/pr.pr_71_17
Abstrakt: Schistosomiasis is the most noteworthy parasitic disease after malaria. Furthermore, the significant activity of the genus Solanum against Schistosoma worms and its intermediate host snails reinforced the study of Solanum seaforthianum Andr. (SS) and Solanum macrocarpon L. (SM) for their molluscicidal and schistosomicidal potentiality. In this study, different extracts, fractions and isolated compounds of both Solanum species are evaluated for the molluscicidal and schistosomicidal potentialities. The niclosamide was used as positive molluscicide control against Biomphalaria alexandrina snails. Different extracts, fractions, or isolated compounds were used at a concentration of 100 μg/ml and dead snails were counted in each case. On the other hand, washed and sterilized Schistosoma mansoni adult worms were used in three replicates, and three worm pairs were placed in each well with 2 ml test solution of 100 μg/ml concentration. Positive (praziquantel [PZQ] 0.2 ug/ml) and negative controls were concurrently used and examined daily for 3 days for viability. The mortality rate was calculated and then both LC 50 and LC 90 were determined in triplicates. Highest potency was indicated to total glycoalkaloid (TGA) fraction of SM followed by TGA of SS. On the other hand, TGA fractions of both species showed higher potency than other extracts and isolated compounds. Meanwhile, solasodine-free aglycone showed declined activity compared to its glycosides. Promising molluscicidal and schistosomicidal activities were displayed which are attributed to the glycoalkaloid content. Therefore, this study can efficiently contribute toward validation of the traditional use of SS and SM in schistosomiasis control.
Summary: The current study evaluated the molluscicidal and schistosomicidal activities of different extracts and fractions of two Solanum species. The glycoalkaloids content depicted a promising activity against both the snails and the adult worms. Abbreviations Used: PZQ; Praziquantel, SM; Solanum macrocarpon , SS; Solanum seaforthianum , TGA; total glycoalkaloid.
Competing Interests: There are no conflicts of interest.
Databáze: MEDLINE
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