Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice.

Autor: Brown M; Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria.; Institute of Science and Technology Austria (IST Austria), 3400 Klosterneuburg, Austria., Assen FP; Institute of Science and Technology Austria (IST Austria), 3400 Klosterneuburg, Austria., Leithner A; Institute of Science and Technology Austria (IST Austria), 3400 Klosterneuburg, Austria., Abe J; Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland., Schachner H; Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria., Asfour G; Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria., Bago-Horvath Z; Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria., Stein JV; Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland., Uhrin P; Institute of Vascular Biology, Medical University of Vienna, 1090 Vienna, Austria., Sixt M; Institute of Science and Technology Austria (IST Austria), 3400 Klosterneuburg, Austria. dontscho.kerjaschki@meduniwien.ac.at michael.sixt@ist.ac.at., Kerjaschki D; Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria. dontscho.kerjaschki@meduniwien.ac.at michael.sixt@ist.ac.at.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2018 Mar 23; Vol. 359 (6382), pp. 1408-1411.
DOI: 10.1126/science.aal3662
Abstrakt: During metastasis, malignant cells escape the primary tumor, intravasate lymphatic vessels, and reach draining sentinel lymph nodes before they colonize distant organs via the blood circulation. Although lymph node metastasis in cancer patients correlates with poor prognosis, evidence is lacking as to whether and how tumor cells enter the bloodstream via lymph nodes. To investigate this question, we delivered carcinoma cells into the lymph nodes of mice by microinfusing the cells into afferent lymphatic vessels. We found that tumor cells rapidly infiltrated the lymph node parenchyma, invaded blood vessels, and seeded lung metastases without involvement of the thoracic duct. These results suggest that the lymph node blood vessels can serve as an exit route for systemic dissemination of cancer cells in experimental mouse models. Whether this form of tumor cell spreading occurs in cancer patients remains to be determined.
(Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje