Exploration of Wedelia chinensis leaf-assisted silver nanoparticles for antioxidant, antibacterial and in vitro cytotoxic applications.
| Autor: | Das MP; Department of Industrial Biotechnology, Bharath University, Chennai 600 073, Tamil Nadu, India., Livingstone JR; Department of Industrial Biotechnology, Bharath University, Chennai 600 073, Tamil Nadu, India., Veluswamy P; Department of Electronics and Material Science, Research Institute of Electronics, Shizuoka University, Hamamatsu 432-8011, Japan., Das J; Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Chennai 603 203, Tamil Nadu, India. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of food and drug analysis [J Food Drug Anal] 2018 Apr; Vol. 26 (2), pp. 917-925. Date of Electronic Publication: 2017 Aug 31. |
| DOI: | 10.1016/j.jfda.2017.07.014 |
| Abstrakt: | Green synthetic route of silver nanoparticles (AgNPs) has already been proved to be an advantageous over other physico-chemical approaches due to its simplicity, cost effectiveness, ecofriendly and nontoxicity. In this finding, aqueous Wedelia chinensis leaf extract (WLE) mediated synthesis of AgNPs was approached. Surface plasmon resonance (SPR) band at 408 nm preliminary indicated the formation of AgNPs, while TEM and XRD characterization confirmed the formation of spherically shaped and crystalline AgNPs with an average size of 31.68 nm, respectively. The plausible biomolecules in the aqueous leaf extract responsible for the reduction and stabilization of AgNPs were identified by FTIR analysis and found to be polyphenolic groups in flavonoid. Further, synthesized AgNPs was explored for different biological applications. Biosynthesized AgNPs showed significant free radical scavenging activity as compared to Wedelia leaf extract and antibacterial activity against clinically isolated test pathogens where Gram-negative bacteria were found more susceptible to AgNPs than Gram-positive one. In addition, in vitro cytotoxic response was also evaluated on hepatocellular carcinoma Hep G2 cell lines and showed a dose-dependent cytotoxic response with an IC (Copyright © 2017. Published by Elsevier B.V.) |
| Databáze: | MEDLINE |
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